High rates of cognitive disorders in antiretroviral-treated people living with HIV have been described worldwide. The exact prevalence of such cognitive disorders is determined by the definitions used, and the presence of these cognitive disorders significantly impacts the overall wellbeing of people with HIV. With the cohort of people with HIV becoming increasingly older, and having high rates of comorbidities and concomitant medication use, rates of cognitive disorders are likely to increase. Conversely, interventions are being sought to reduce the size of the latent HIV reservoir. If successful, such interventions are likely to also reduce the HIV reservoir in the brain compartment, which could result in improvements in cognitive function and reduced rates of impairment.

世界范围内已经描述了在抗逆转录病毒治疗的艾滋病毒感染者中认知障碍的发生率很高。此类认知障碍的确切患病率取决于所使用的定义，这些认知障碍的存在会显着影响艾滋病毒感染者的整体健康。随着艾滋病病毒感染者的年龄越来越大，合并症和伴随药物的使用率很高，认知障碍的发生率可能会增加。相反，正在寻求干预措施以减少潜在的艾滋病毒储存库的规模。如果成功，这种干预措施也可能会减少脑室内的HIV储存，这可能会导致认知功能的改善和受损率的降低。