当前位置: X-MOL 学术Neurobiol. Learn. Mem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
On the role of the dopaminergic system in the memory deficits induced by maternal deprivation.
Neurobiology of Learning and Memory ( IF 2.7 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.nlm.2020.107272
Ben-Hur Souto Neves 1 , Gabriel Palermo Del Rosso Barbosa 1 , Ana Carolina de Souza Rosa 1 , Steffanie Severo Picua 1 , Gabriela Mendes Gomes 1 , Priscila Marques Sosa 1 , Pâmela Billig Mello-Carpes 1
Affiliation  

Previous researches showed that maternal deprivation (MD) leads to memory deficits that persist until adulthood. The hippocampus, an important brain structure involved in memory processes, receives dopaminergic afferents from other brain areas that modulate memory. Here we demonstrated that MD results in object recognition memory deficits that are reverted by intra-hippocampal stimulation of D1-dopaminergic receptor and peripheral administration of a dopamine precursor. The D1-dopaminergic receptor and peripheral administration of a dopamine precursor also promoted memory persistence in control rats.



中文翻译:

关于多巴胺能系统在母体剥夺引起的记忆缺陷中的作用。

先前的研究表明,母体剥夺(MD)会导致记忆力减退,一直持续到成年。海马是参与记忆过程的重要大脑结构,它从其他调节记忆的大脑区域接受多巴胺能传入。在这里,我们证明了MD导致对象识别记忆缺陷,该缺陷可通过海马内D1-多巴胺能受体刺激和外周给予多巴胺前体来恢复。D1-多巴胺能受体和多巴胺前体的外周给药也促进了对照组大鼠的记忆持久性。

更新日期:2020-07-06
down
wechat
bug