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Fed Macrophages Hit the Liver's Sweet Spot with IL-10.
Molecular Cell ( IF 16.0 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.molcel.2020.06.016
André Sulen 1 , Myriam Aouadi 2
Affiliation  

In this issue of Molecular Cell, Toda et al. (2020) show that postprandial elevation of LPS and insulin induce the production of IL-10 by adipose tissue macrophages. Hepatic gluconeogenesis is then inhibited synergistically by insulin and IL-10 to facilitate glucose clearance.



中文翻译:

美联储巨噬细胞以IL-10达到肝脏的最佳治疗点。

在本期《分子细胞》中,Toda等人。(2020)表明,餐后LPS和胰岛素升高可诱导脂肪组织巨噬细胞产生IL-10。然后,胰岛素和IL-10协同抑制肝糖异生,以促进葡萄糖清除。

更新日期:2020-07-02
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