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Synthesis of Carbon Nitride Quantum Dots and Biocompatibility Evaluation using C. Elegans as a Model Organism
Materials Today Communications ( IF 3.8 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.mtcomm.2020.101383
Hualing Li , Chengxin Fei , Di Yang , Chuan Tan , Zhangyue Chen , Jun Wang , Guoxiu Wang , Hongying Fan , Hang Yao , Chengyin Wang , Hui Chong

Carbon nitride quantum dots (CNQDs) were synthesized by the solid-phase method. The obtained CNQDs were characterized by XPS, TEM, FTIR and XRD. The results suggested that the CNQDs were ball-like nanoparticles (average diameter of 5 nm) with carboxyl and hydroxyl groups on the surface. The fluorescent emissions of the CNQDs were centered at 478 nm upon excitation with 365 nm UV light. The corresponding fluorescent quantum yield was measured as 32%. The biocompatibility of the CNQDs with the model organismCaenorhabditiselegans (C. elegans) was systematically evaluated. The synthesized CNQDs enhanced the pharyngeal pumping rate, body length and life span of nematodes in a concentration-dependent manner after 24 hours of exposure. Thus, the CNQDs affected the growth of the nematodes. The reproduction and motion capability indicators, including the egg laying rate and head thrash and body bend frequencies, were not influenced by the CNQDs. Therefore, the CNQDs did not show obvious toxicity to theC. elegansnematode model organism. The CNQDs could be taken up by nematodes, as characterized by fluorescence microscopy, proving that this material could be applied as a promisingin vivofluorescent imaging reagent.



中文翻译:

碳氮化物量子点的合成和生物相容性评价以线虫为模型生物

用固相法合成了氮化碳量子点(CNQDs)。通过XPS,TEM,FTIR和XRD对获得的CNQD进行了表征。结果表明,CNQD是球形的纳米颗粒(平均直径为5 nm),表面具有羧基和羟基。在用365 nm紫外光激发后,CNQD的荧光发射集中在478 nm。测得相应的荧光量子产率为32%。系统评估了CNQD与模型生物秀丽隐杆线虫(C. elegans)的生物相容性。暴露24小时后,合成的CNQD以浓度依赖的方式提高了线虫的咽抽动率,体长和寿命。因此,CNQD影响了线虫的生长。再现和运动能力指标,包括产卵率,头部跳动和身体弯曲频率在内,不受CNQD的影响。因此,CNQD对C没有明显的毒性。线虫模型生物。CNQDs可以被线虫吸收,如荧光显微镜所证实的那样,证明这种材料可以作为一种有前途的应用体内荧光成像试剂。

更新日期:2020-07-02
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