Abstract Biodegradable Mg-based alloys have attracted increasing attention from orthopedic surgeons and biomaterials scientists since their Young’s modulus is close to that of bone. However, control of the degradation rate is still a challenge. Sputtered TiO2 coatings were deposited on Mg-Zn-Ca alloys aiming to reduce the initial strong reactivity of Mg with biological fluids. However, the degradation tests indicated that the coated samples induced a larger variation in the pH, greater H2 production and formation of degradation products in comparison to the bare alloys. Consequently, an enhanced cytotoxicity of the coated samples was observed.

中文翻译：

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TiO2 涂层镁合金的意外细胞毒性

摘要 可生物降解的镁基合金由于其杨氏模量接近骨骼，因此越来越受到骨科医生和生物材料科学家的关注。然而，控制降解率仍然是一个挑战。溅射的 TiO2 涂层沉积在 Mg-Zn-Ca 合金上，旨在降低 Mg 与生物流体的初始强反应性。然而，降解试验表明，与裸合金相比，涂层样品引起了更大的 pH 变化、更多的 H2 产生和降解产物的形成。因此，观察到包被样品的细胞毒性增强。