The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.,Journal of the American Academy of Dermatology

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The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.
Journal of the American Academy of Dermatology ( IF 13.8 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.jaad.2020.06.1016
Esther E Freeman ₁ , Devon E McMahon ₂ , Jules B Lipoff ₃ , Misha Rosenbach ₃ , Carrie Kovarik ₃ , Seemal R Desai ₄ , Joanna Harp ₅ , Junko Takeshita ₃ , Lars E French ₆ , Henry W Lim ₇ , Bruce H Thiers ₈ , George J Hruza ₉ , Lindy P Fox ₁₀

Affiliation

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts.
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas; Innovative Dermatology, Plano, Texas.
Department of Dermatology, Weill Cornell Medicine, New York, New York.
Department of Dermatology, University Hospital, Munich University of Ludwig Maximilian, Munich, Germany; Department of Dermatology, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
Department of Dermatology, Henry Ford Health System, Detroit, Michigan.
Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina.
Department of Dermatology, St. Louis University, St Louis, Missouri.
Department of Dermatology, University of California San Francisco, San Francisco, California.

Background

Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.

Objective

To characterize the diversity of cutaneous manifestations of COVID-19 and facilitate understanding of the underlying pathophysiology.

Methods

Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies.

Results

The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry with laboratory-confirmed COVID-19, the most common morphologies were morbilliform (22%), pernio-like (18%), urticarial (16%), macular erythema (13%), vesicular (11%), papulosquamous (9.9%), and retiform purpura (6.4%). Pernio-like lesions were common in patients with mild disease, whereas retiform purpura presented exclusively in ill, hospitalized patients.

Limitations

We cannot estimate incidence or prevalence. Confirmation bias is possible.

Conclusions

This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were nonspecific, whereas others may provide insight into potential immune or inflammatory pathways in COVID-19 pathophysiology.

中文翻译：

COVID-19 相关皮肤病表现的范围：来自 31 个国家的 716 名患者的国际登记。

背景

2019 年冠状病毒病 (COVID-19) 具有相关的皮肤表现。

客观的

描述 COVID-19 皮肤表现的多样性并促进对潜在病理生理学的理解。

方法

来自美国皮肤病学会和国际皮肤病学会联盟国际登记的病例系列。

结果

该登记处收集了 716 例确诊/疑似 COVID-19 患者新发皮肤症状的病例。在登记处的 171 名实验室确诊的 COVID-19 患者中，最常见的形态是麻疹状 (22%)、冻疮样 (18%)、荨麻疹 (16%)、黄斑红斑 (13%)、水疱状 (11 %）、丘疹鳞状上皮性（9.9%）和网状紫癜（6.4%）。冻疮样病变常见于病情较轻的患者，而网状紫癜仅出现在患病住院患者中。