The ever increasing demand for nanoantioxidants with minimized toxicity dictates the necessity to develop new biocompatible materials. One promising approach is the immobilization of polyphenols on metal (oxy)hydroxide nanoparticles (NPs) that possess the desired chemical and colloidal stability while also allowing to dispose of the antioxidants more safely and effectively. In this paper we modify sol-gel synthesized γ-AlOOH NPs with curcumin molecules. The prepared colloidal systems are hydrosols, stable in acidic, neutral and slightly basic pH values. UV–vis and FTIR spectroscopies suggest that the mechanism of curcumin binding lies in the H-bonding of its functional groups to hydroxyls of pseudoboemite. Modification of AlOOH nanoparticles shifts its isoelectric point from 9.7 to 9.3 due to the weak acidic centers of the polyphenol. Immobilization of curcumin molecules on pseudoboehmite allows to achieve good solubility of the phenol in water and to reduce the level of its hemolytic activity (indicating good biocompatibility). At the same time, it preserves radical scavenging activity and in some experimental designs even enhances antioxidant and membrane-protective activity (enhancement ≥30%) in vitro on cellular and non-cellular models.

对具有最小化毒性的纳米抗氧化剂的不断增长的需求决定了开发新的生物相容性材料的必要性。一种有前途的方法是将多酚固定在具有所需化学和胶体稳定性的金属（羟基）氢氧化物纳米粒子（NP）上，同时还可以更安全有效地处理抗氧化剂。在本文中，我们用姜黄素分子修饰了溶胶-凝胶合成的γ-AlOOHNP。制备的胶体体系为水溶胶，在酸性，中性和弱碱性pH值下均稳定。UV-vis和FTIR光谱表明，姜黄素结合的机理在于其官能团与假Boemite羟基的H键结合。由于多酚的弱酸性中心，AlOOH纳米颗粒的改性将其等电点从9.7转移到9.3。将姜黄素分子固定在假勃姆石上可以实现苯酚在水中的良好溶解度，并降低其溶血活性水平（表明良好的生物相容性）。同时，它保留了自由基清除活性，并且在某些实验设计中甚至在体外在细胞和非细胞模型上增强了抗氧化剂和膜保护活性（增强≥30％）。