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Polyphenolic-enriched peach peels extract regulates lipid metabolism and improves the gut microbiota composition in high fat diet-fed mice
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.jff.2020.104082
Juan Kan , Cuicui Chen , Tongbin Huo , Wangjin Xie , Yaoyao Hui , Jun Liu , ChangHai Jin

Polyphenols possess a reduction in the risk of a number of metabolic disorders. Peach peel contains plenty of polyphenols; however, its effect on regulating lipid metabolism remains unclear. The objective of this study was to investigate the effects of peach peel extract (PPE) on lipid metabolism and gut microbiota composition of high fat diet (HFD)-induced obesity mice. HPLC/DAD/ESI-MS indicated that there were a total of 19 polyphenolic compounds in PPE. PPE significantly inhibited lipid accumulation in HFD-fed mice. Meanwhile, PPE treatment regulated mRNA expression levels involved in lipid metabolism. The results from 16S rRNA sequencing showed that PPE regulated the composition of intestinal microbiota, increasing the relative abundance of Lactobacillus, Bacteroides, Lachnospiraceae, Prevotellaceae, Alloprevotella, Akkermansia, Roseburia, and Ruminococcus, which were positively associated with symptomatic resistance to HFD. Our findings suggested that PPE may be used as an additive of functional food to improve the lipid metabolic abnormalities associated with obesity.



中文翻译:

富含多酚的桃皮提取物调节高脂饮食喂养小鼠的脂质代谢并改善肠道菌群组成

多酚可降低许多代谢紊乱的风险。桃皮中含有大量的多酚。但是,其调节脂质代谢的作用尚不清楚。这项研究的目的是研究桃皮提取物(PPE)对高脂饮食(HFD)诱导的肥胖小鼠脂质代谢和肠道微生物群组成的影响。HPLC / DAD / ESI-MS表明,PPE中总共有19种多酚化合物。PPE显着抑制了由HFD喂养的小鼠的脂质蓄积。同时,PPE处理可调节参与脂质代谢的mRNA表达水平。16S rRNA测序结果表明,PPE调节肠道菌群的组成,增加了乳酸杆菌拟杆菌毛螺PrevotellaceaeAlloprevotella,Akkermansia,罗斯氏,瘤胃球菌属,其均与到HFD对症抗性相关。我们的发现表明,PPE可以用作功能性食品的添加剂,以改善与肥胖相关的脂质代谢异常。

更新日期:2020-07-02
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