Abstract The largest collection of Schiff base metal complexes have been synthesized and characterized with 4-aminoantipyrine and its derivatives with some aldehydes and ketones. The Schiff base ligand (L) is prepared from 4-aminoantipyrine, acetamide and p-phenylenediamine. Metal salts used to synthesize these complexes are Co(II), Ni(II), Cu(II) and Zn(II) acetates. The elemental analysis results are in accordance with the proposed formula assigned to these complexes. Mass spectrum of the ligand and its metal complexes were recorded. The molecular ion peaks confirm the stoichiometry of the Schiff base ligand and metal complexes. In IR spectra, the imine band is shifted to lower wave number in the complexes. UV spectral studies suggest square planar geometry for Co(II), Ni(II), Cu(II), complexes and tetrahedral geometry for Zn(II). The grain size of the metal complexes was estimated by Scherrer equation using powder XRD. In the present study, the ligand and its metal complexes are found to be nano crystalline in nature. The synthesized complexes show higher photo catalytic activity under UV-spectra using methylene blue dye. Thermal decomposition is in covenant with proposed formulation of the complexes. Irreversible redox behavior of the complex was identified by cyclic voltammetric analysis. Molecular structures of the synthesized ligand and metal complexes have been optimized by DFT computations. DNA binding and DNA cleavage studies of the compounds were investigated. Antibacterial analysis were also done against four bacterial species, viz (B. Substilis, S. Aureus, E. Coli and K. Pneumoniae) and two fungal species such as (A. Niger and C. Albicans). Cytotoxicity of complexes has been tested against L929 fibroblast cell line. Anticancer activity of ligand and its complexes are evaluated using SK-MEL-28 cell line.

中文翻译：

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4-氨基安替比林、乙酰胺和对苯二胺衍生的席夫碱金属配合物的合成、表征和生物学研究

摘要 最大的席夫碱金属配合物已被合成并表征为 4-氨基安替比林及其衍生物与一些醛和酮。席夫碱配体 (L) 由 4-氨基安替比林、乙酰胺和对苯二胺制备。用于合成这些配合物的金属盐是 Co(II)、Ni(II)、Cu(II) 和 Zn(II) 醋酸盐。元素分析结果与指定给这些配合物的建议式一致。记录配体及其金属配合物的质谱。分子离子峰证实了席夫碱配体和金属配合物的化学计量。在红外光谱中，亚胺带移动到复合物中的较低波数。紫外光谱研究表明 Co(II)、Ni(II)、Cu(II)、配合物为方形平面几何形状，Zn(II) 为四面体几何形状。金属配合物的晶粒尺寸通过使用粉末 XRD 的 Scherrer 方程估计。在本研究中，发现配体及其金属配合物本质上是纳米晶体。合成的配合物在使用亚甲蓝染料的紫外光谱下显示出更高的光催化活性。热分解与建议的配合物配方一致。通过循环伏安分析确定了复合物的不可逆氧化还原行为。合成配体和金属配合物的分子结构已通过 DFT 计算进行了优化。研究了化合物的 DNA 结合和 DNA 切割研究。还针对四种细菌物种进行了抗菌分析，即（枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌和肺炎克雷伯氏菌）和两种真菌物种，例如（A. Niger 和 C. Albicans）。已针对 L929 成纤维细胞系测试了复合物的细胞毒性。使用 SK-MEL-28 细胞系评估配体及其复合物的抗癌活性。