The serine/arginine rich proteins (SR proteins) are members of a family of RNA binding proteins involved in regulating various features of RNA metabolism, including pre-mRNA constitutive and alternative splicing. In humans, a total of 12 SR splicing factors (SRSFs) namely SRSF1-SRSF12 have been reported. SRSF3, the smallest member of the SR family and the focus of this review, regulates critical steps in mRNA metabolism and has been shown to have mRNA-independent functions as well. Recent studies on SRSF3 have uncovered its role in a wide array of complex biological processes. We have also reviewed the involvement of SRSF3 in disease conditions like cancer, ageing, neurological and cardiac disorders. Finally, we have discussed in detail the autoregulation of SRSF3 and its implications in cancer and commented on the potential of SRSF3 as a therapeutic target, especially in the context of cancer.

富含丝氨酸/精氨酸的蛋白（SR蛋白）是RNA结合蛋白家族的成员，参与调节RNA代谢的各种特征，包括前mRNA组成型和可变剪接。在人类中，总共报告了12个SR剪接因子（SRSF），即SRSF1-SRSF12。SRSF3是SR家族的最小成员，也是本综述的重点，它调节mRNA代谢中的关键步骤，并且还显示出具有mRNA依赖性的功能。SRSF3的最新研究发现了它在一系列复杂的生物过程中的作用。我们还审查了SRSF3在疾病状况（如癌症，衰老，神经系统疾病和心脏疾病）中的参与。最后，