The relationship between endocrine system disorders and health risks due to chemical environmental compounds has become a growing concern in recent years. Involuntary exposure to endocrine disruptors (EDCs) is associated with the worldwide increase of diseases such as cancer, obesity, diabetes, and neurocortical disorders. EDCs are compounds that target the nuclear hormonereceptors (NHR) leading to epigenetic changes. Consequently, the use of biosensing strategies based on epigenetic events have a great potential to provide outstanding information about the exposition of EDCs and their evaluation in human health. This review addresses the novel trends in biosensing EDCs evaluation based on DNA methylation assays associated with different human diseases.

近年来，由于化学环境化合物引起的内分泌系统疾病与健康风险之间的关系日益引起人们的关注。非自愿接触内分泌干扰物（EDC）与世界范围内疾病的增加有关，例如癌症，肥胖症，糖尿病和神经皮质疾病。EDC是靶向导致表观遗传变化的核激素受体（NHR）的化合物。因此，基于表观遗传事件的生物传感策略的使用具有巨大的潜力，可以提供有关EDC的暴露及其对人类健康的评估的出色信息。这篇评论提出了基于与不同人类疾病相关的DNA甲基化分析的生物传感EDC评估中的新趋势。