Background

Recent studies suggest that high pre-diagnostic serum concentrations of persistent organic pollutants (POPs) might result in the development of cancers in the general population. However, the association between pre-diagnostic serum POP concentrations and lung cancer risk has not been studied. Here, we evaluated associations between low-dose environmental exposure to POPs and risk of lung cancer using pre-diagnostic serum samples in a case-cohort study based on a population-based prospective cohort.

Methods

We conducted a case-cohort study based on the Korean National Cancer Center Community Cohort, from which we included 118 lung cancer cases and 252 controls. Serum concentrations of POPs were measured by high resolution gas chromatography/high-resolution mass spectrometry, and data were analyzed using multivariable Cox proportional-hazards regression models.

Results

Risk of lung cancer increased per unit increase in the natural log-transformed concentrations of the sum of chlordane congeners, total PCBs, and all PCBs subgrouped by the number of chlorines or ortho- substituted chlorines on the molecules, except for tri/tetrachlorobiphenyls, in all models. Among individual POP analytes with a detection rate >80%, after Bonferroni adjustment, only trans-nonachlor was associated with lung cancer risk. In categorical models, risk of lung cancer was associated with serum concentration of chlordane (4th vs. 1st quartile, hazard ratio [95% confidence interval], 8.79 [2.77–27.97]). Dose-dependent relationships were also found between risk of lung cancer and serum concentrations of PCBs regardless of their degree of chlorination, substitution pattern, or binding affinity to receptors (total PCBs, P = 0.002; mid-chlorinated PCBs, P = 0.004; high-chlorinated PCBs, P < 0.001; non- and mono-ortho PCBs, P = 0.031; di-ortho PCBs, P = 0.003; PCBs with dioxin-like activity, P = 0.011; non-dioxin-like non-/mono-ortho PCBs, P = 0.060).

Conclusions

Serum concentrations of chlordane and PCBs are associated with risk of lung cancer in the general population, even decades after the ban on their production and use.

中文翻译：

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环境中暴露于持久性有机污染物对肺癌风险的影响。

背景

最近的研究表明，持久性有机污染物（POPs）的高诊断前血清浓度可能导致普通人群罹患癌症。但是，尚未研究诊断前血清POP浓度与肺癌风险之间的关系。在这里，我们在一项基于人群的前瞻性队列研究的病例队列研究中，使用了预诊断血清样本评估了低剂量环境中持久性有机污染物暴露与肺癌风险之间的关联。

方法

我们基于韩国国家癌症中心社区队列进行了病例队列研究，其中包括118例肺癌病例和252例对照。POPs的血清浓度通过高分辨率气相色谱/高分辨率质谱仪测量，并使用多变量Cox比例风险回归模型分析数据。

结果

氯丹烃，总多氯联苯和所有多氯联苯之和的自然对数转化浓度每单位升高的肺癌风险，将分子中除三/四氯联苯以外的氯或邻位取代氯的数量所分组。所有型号。在Bonferroni调整后，检测率> 80％的单个POP分析物中，仅反-壬草胺与肺癌风险有关。在分类模型中，肺癌风险与血清中的氯丹浓度相关（第4比第1四分位数，危险比[95％置信区间]，8.79 [2.77–27.97]）。还发现肺癌风险与多氯联苯的血清浓度之间存在剂量依赖性关系，无论其氯化程度，取代模式或与受体的结合亲和力如何（总多氯联苯，P  = 0.002；中度多氯联苯，P  = 0.004；高-chlorinated多氯联苯，P  <0.001;非和单邻多氯联苯，P  = 0.031;二-邻多氯联苯，P  = 0.003;与二恶英类的活性，多氯联苯P = 0.011; 非二恶英类非/单邻多氯联苯，P  = 0.060）。

结论

甚至在禁止生产和使用数十年后，普通人群的血清中氯丹和多氯联苯的浓度与患肺癌的风险有关。