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Salt-Responsive Polyzwitterion Brushes Conjugated with Silver Nanoparticles: Preparation and Dual Antimicrobial/Release Properties
Chemical Engineering Journal ( IF 15.1 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.cej.2020.126114
Bang Liang , Erna Jia , Xiaodie Yuan , Guangyu Zhang , Zhaohui Su

Attachment and colonization of bacteria on surfaces seriously impact human health as well as numerous technologies. In this contribution, a new zwitterionic monomer, 3-(dimethyl(4-vinylbenzyl)ammonio)butanesulfonate (DVBABS), was synthesized and a polymeric coating that not only kills bacteria but also releases them afterwards was constructed through rapid deposition of polydopamine (PDA) followed by in situ synthesis of Ag nanoparticles (NPs) and finally by grafting of polyDVBABS brushes using ARGET-ATRP (activators regenerated by electron transfer for atom transfer radical polymerization). The PDA catechol groups immobilized the Ag NPs, which were responsible for the inhibition of bacterial growth, and a change from water to salt solution effected a reversible conformational transition of the polyzwitterion, which was responsible for bacterial release. For both Escherichia coli (E. coli) and Staphylococcus (S. aureus), the dual-function coating can kill ≥99% of attached bacteria and then rapidly release ≥95% of all attached bacteria. Both functions were well retained over several cycles of killing and release. Based on the substrate-independent adhesion of PDA coatings, exemplified here for titanium, cotton textile, polypropylene and polydimethylsiloxane surfaces, a broad spectrum of applications are envisaged.



中文翻译:

与银纳米粒子共轭的盐敏感型聚两性离子刷:制备和双重抗菌/释放特性

细菌在表面的附着和定殖严重影响人类健康以及众多技术。在这一贡献中,合成了一种新的两性离子单体3-(二甲基(4-乙烯基苄基)铵)丁磺酸盐(DVBABS),并且通过快速沉积聚多巴胺(PDA)构造了一种聚合物涂层,该涂层不仅可以杀死细菌,还可以释放细菌。 ),然后就地合成Ag纳米粒子(NPs),最后使用ARGET-ATRP(通过电子转移再生的活化剂进行原子转移自由基聚合而接枝了polyDVBABS刷)。PDA邻苯二酚基团固定了可抑制细菌生长的Ag NPs,从水变成盐溶液的变化可引起多两性离子的可逆构象转变,这是导致细菌释放的原因。对于大肠杆菌E. coli)和金黄色葡萄球菌S. aureus)),双重功能涂层可以杀死≥99%的附着细菌,然后迅速释放≥95%的所有附着细菌。这两个功能在杀死和释放的几个周期中都得到了很好的保留。基于PDA涂层的不依赖于基材的粘附力,在此举例说明了钛,棉纺织品,聚丙烯和聚二甲基硅氧烷表面的涂层,可以设想广泛的应用范围。

更新日期:2020-07-02
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