Obesity disrupts physiological homeostasis and alters both systemic and local microenvironments that impact stem cell plasticity and impair regenerative capacity. We present growing evidence that reveals the bidirectionality of obesity-induced stem cell dysfunction and how the molecular changes in stem cells residing in obese environments may accelerate disease severity.

中文翻译：

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肥胖是一种干细胞疾病吗？

肥胖会破坏生理稳态并改变影响干细胞可塑性和损害再生能力的全身和局部微环境。我们提供了越来越多的证据，这些证据揭示了肥胖诱导的干细胞功能障碍的双向性，以及存在于肥胖环境中的干细胞的分子变化如何可能加速疾病的严重程度。