Intelligent drug delivery systems (DDS), integrating with multi-modal imaging guidance and controlled drug release, have practical significance in enhancing the therapeutic efficiency of tumors. Herein, fluorinated aza-boron-dipyrromethene (NBF) with high near-infrared absorption is synthesized by introducing nonadecafluorodecanoic acid into aza-BODIPY via the amide bond. Through the co-precipitation methods, nanoparticles (NPs) based on NBF are fabricated and the obtained NBF NPs can not only load with DOX with a high loading efficiency (25%, DNBF NPs), but also absorb PFC droplets (1H-perfluoropentane) with bp of 42 °C because of the fluorinated chains inside NBF NPs (PDNBF NPs). Under 808-nm laser irradiation, the hyperthermia effect of NBF could induce the liquid-gas phase transition of PFC droplets, triggering the burst release of DOX and enhancing echo signals for ultrasound imaging as well. With efficient enrichment of PDNBF NPs at tumor site as revealed by in vivo ultrasound imaging and photoacoustic imaging, significant improvement in inhibiting tumor growth is achieved with PDNBF NPs under laser irradiation without noticeable side effects. The work presents a multifunctional organic DDS with great biocompatibility, high drug loading efficiency and light-stimuli-responsive drug release, which provides a new strategy for the manufacture of intelligent composite theranostic nanoplatform.

智能药物输送系统（DDS）与多模式成像指导和受控药物释放相结合，对提高肿瘤的治疗效率具有实际意义。在此，通过经由酰胺键将壬二氟癸酸引入到氮杂-BODIPY中来合成具有高近红外吸收的氟化的氮杂硼-双-吡咯二烯（NBF）。通过共沉淀法，制备了基于NBF的纳米颗粒（NPs），所得NBF NPs不仅可以高负载效率（25％，DNBF NPs）负载DOX，而且可以吸收PFC液滴（1H-全氟戊烷）由于NBF NP（PDNBF NP）内部有氟化链，因此bp为42°C。在808 nm激光照射下，NBF的热疗效应可引起PFC液滴的液相-气相转变，触发DOX的突发释放并增强超声成像的回波信号。体内超声成像和光声成像显示，通过有效富集肿瘤部位的PDNBF NP，在激光照射下使用PDNBF NP可以显着改善抑制肿瘤生长的作用，而没有明显的副作用。这项工作提出了一种具有良好的生物相容性，高载药效率和光刺激响应性药物释放的多功能有机DDS，这为制造智能复合治疗药物纳米平台提供了新的策略。使用PDNBF NP在激光照射下可显着改善抑制肿瘤生长的效果，而无明显副作用。这项工作提出了一种具有良好的生物相容性，高载药效率和光刺激响应性药物释放的多功能有机DDS，为制备智能复合治疗药物纳米平台提供了新的策略。使用PDNBF NP在激光照射下可显着改善抑制肿瘤生长的效果，而无明显副作用。这项工作提出了一种具有良好的生物相容性，高载药效率和光刺激响应性药物释放的多功能有机DDS，这为制造智能复合治疗药物纳米平台提供了新的策略。