Quarantine is a well-known risk factor for psychological and psychiatric disturbances. We evaluated burden of migraine during lockdown due to COVID 19 pandemia. Forty-nine subjects followed in our headache clinic for migraine were evaluated for migraine burden by means of global assessment of migraine severity (GAMS) and visual analogue scale (VAS) by phone interview. Moreover, depression and anxiety were quantified by Beck depression inventory (BDI) and Zung Self-Rating Anxiety Scale (SAS). We evaluated changes in the value of migraine score from the 2 months immediately before lockdown (from January 1 to March 9) to the 2 months of quarantine (from March 10 to May 3). Value of GAMS was 5.61 ± 0.76 before and 4.16 ± 1.46 during quarantine (p < .001). VAS was 7.49 ± 1.10 before and 5.47 ± 1.88 during quarantine (p < .001). We also found a time by depression level interaction, F(1,47) = 6.21, p = .016, F(1,47) = 14.52, p < .006, respectively, showing that subjects with lower level of depression had better course of migraine. In conclusion, we showed that, during quarantine due to COVID pandemia, subjects with migraine had fewer migraine attacks and lesser pain and show moderate level of depression, correlated to migraine burden.

隔离是心理和精神疾病的众所周知的危险因素。我们评估了由于COVID 19大流行而在锁定期间的偏头痛负担。通过电话采访对偏头痛的严重程度（GAMS）和视觉模拟量表（VAS）进行整体评估，对在我们头痛诊所进行偏头痛的49位受试者的偏头痛负担进行了评估。此外，通过贝克抑郁量表（BDI）和Zung自评焦虑量表（SAS）量化抑郁和焦虑。我们评估了从禁闭前的两个月（从1月1日到3月9日）到隔离的2个月（从3月10日到5月3日）偏头痛评分的变化。GAMS检疫前值为5.61±0.76，检疫时为4.16±1.46（p<.001）。隔离前的VAS为7.49±1.10，隔离期间为5.47±1.88（p <.001）。我们还发现了与抑郁水平相互作用的时间，分别为F（1,47）= 6.21，p = .016，F（1,47）= 14.52，p <.006，这表明抑郁水平较低的受试者有更好的偏头痛病程。总之，我们表明，在因COVID大流行而导致的隔离期间，偏头痛患者的偏头痛发作次数较少，疼痛较少，并且表现出中等程度的抑郁感，与偏头痛负担相关。