The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternatives in this scenario. Genus Uvaria is a part of Annonaceae family, while the majority of its species are widely distributed in tropical rain forest regions of South East Asia. Uvaria species have been used extensively used as traditional medicine for treating all sorts of inflammatory diseases including catarrhal inflammation, rheumatism, acute allergic reactions, hemorrhoids, inflammatory liver disease and inflamed joints. Phytochemical analysis of Uvaria species has revealed flavones, flavonoids, tannins, saponins, polyoxygenated cyclohexene and phenolic compounds as major phyto-constituents. This review is an attempt to highlight the anti-inflammatory activity of Uvaria species by conducting a critical appraisal of the published literature. The ethnopharmacological relevance of Uvaria species in the light of toxicological studies is also discussed herein. An extensive and relevant literature on anti-inflammatory activity of Uvaria species was collected from available books, journals and electronic databases including PubMed, ScienceDirect, Scopus, Proquest and Ovid. Extracts and isolates of Uvaria species exhibited significant anti-inflammatory activity through various mechanisms of action. 6,7-di-O-Methyl-baicalein, flexuvarol B, chrysin, (−)-zeylenol, 6-hydroxy-5,7-dimethoxy-flavone, and pinocembrin were the most potent anti-inflammatory compounds with comparable IC₅₀ with positive controls. Therefore, it is suggested that further research should be carried out to determine the pharmacokinetics, pharmacodynamics and toxicity of these therapeutically significant compounds, to convert the pre-clinical results into clinical data for drug development and design.

当代抗炎药的治疗功效已得到公认；然而，长期使用此类药物通常会导致严重且危及生命的副作用。在这种情况下，具有卓越功效和最小毒性的基于天然产物的抗炎化合物可以作为可能的治疗选择。Uvaria属是番荔枝科的一部分，而其大部分物种广泛分布于东南亚的热带雨林地区。Uvaria种类已被广泛用作传统药物，用于治疗各种炎症疾病，包括卡他性炎症、风湿病、急性过敏反应、痔疮、炎症性肝病和关节发炎。Uvaria 的植物化学分析物种发现黄酮、黄酮类化合物、单宁、皂苷、多氧化环己烯和酚类化合物是主要的植物成分。本综述试图通过对已发表文献的批判性评估来强调Uvaria物种的抗炎活性。根据毒理学研究，Uvaria物种的民族药理学相关性也在本文中进行了讨论。从包括 PubMed、ScienceDirect、Scopus、Proquest 和 Ovid 在内的现有书籍、期刊和电子数据库中收集了大量关于Uvaria物种抗炎活性的相关文献。Uvaria 的提取物和分离物物种通过各种作用机制表现出显着的抗炎活性。6,7-二-O-甲基-黄芩素、flexuvarol B、白杨素、(-)-玉米烯醇、6-羟基-5,7-二甲氧基-黄酮和松香素是最有效的抗炎化合物，IC ₅₀与阳性对照。因此，建议进一步研究确定这些具有治疗意义的化合物的药代动力学、药效学和毒性，将临床前结果转化为临床数据用于药物开发和设计。