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Androgens' effects on cerebrovascular function in health and disease.
Biology of Sex Differences ( IF 7.9 ) Pub Date : 2020-06-30 , DOI: 10.1186/s13293-020-00309-4
Charly Abi-Ghanem 1 , Lisa S Robison 1 , Kristen L Zuloaga 1
Affiliation  

Androgens affect the cerebral vasculature and may contribute to sex differences in cerebrovascular diseases. Men are at a greater risk for stroke and vascular contributions to cognitive impairment and dementia (VCID) compared to women throughout much of the lifespan. The cerebral vasculature is a target for direct androgen actions, as it expresses several sex steroid receptors and metabolizing enzymes. Androgens’ actions on the cerebral vasculature are complex, as they have been shown to have both protective and detrimental effects, depending on factors such as age, dose, and disease state. When administered chronically, androgens are shown to be pro-angiogenic, promote vasoconstriction, and influence blood-brain barrier permeability. In addition to these direct effects of androgens on the cerebral vasculature, androgens also influence other vascular risk factors that may contribute to sex differences in cerebrovascular diseases. In men, low androgen levels have been linked to metabolic and cardiovascular diseases including hypertension, diabetes, hyperlipidemia, and obesity, which greatly increase the risk of stroke and VCID. Thus, a better understanding of androgens’ interactions with the cerebral vasculature under physiological and pathological conditions is of key importance.

中文翻译:

雄激素对健康和疾病中脑血管功能的影响。

雄激素影响脑血管,可能导致脑血管疾病的性别差异。与女性相比,男性在其整个生命周期中的中风和血管对认知障碍和痴呆症(VCID)的贡献更大。脑血管系统是直接雄激素作用的靶标,因为它表达了几种性类固醇受体和代谢酶。雄激素对脑血管的作用是复杂的,因为已证明它们具有保护作用和有害作用,具体取决于年龄,剂量和疾病状态等因素。长期服用时,雄激素表现出促血管生成作用,促进血管收缩并影响血脑屏障通透性。除了雄激素对脑血管的直接作用外,雄激素还影响其他可能导致脑血管疾病性别差异的血管危险因素。在男性中,低雄激素水平已与代谢和心血管疾病(包括高血压,糖尿病,高脂血症和肥胖症)相关,这大大增加了中风和VCID的风险。因此,更好地了解在生理和病理条件下雄激素与脑血管的相互作用至关重要。
更新日期:2020-07-01
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