Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.

中文翻译：

---

轻度创伤性脑损伤急性期的脑血流及其连通性不足。

目标。轻度脑外伤（mTBI）后认知障碍对脑血管灌注的影响已受到广泛关注，但轻度脑外伤（mTBI）基于动脉自旋标记（ASL）的静息状态脑血流（CBF）连通性改变）仍不清楚。这项研究调查了急性mTBI患者的区域CBF和CBF连通性特征，以及CBF变化与认知障碍之间的关联。材料和方法。45例急性mTBI患者和42名健康对照者进行了伪连续动脉自旋标记（pCASL）灌注磁共振成像（MRI）。检测区域CBF的变化以及CBF变化与认知障碍之间的关系。还在两组之间比较了大脑区域的ASL-CBF连通性与区域CBF的显着差异。神经心理学测试涵盖了七个认知领域。CBF变化和认知障碍之间的关联进行了进一步调查。结果。与健康对照组相比，急性mTBI患者双侧下颞回（ITG）的CBF升高，右中额回（MFG），双侧上额回（SFG）和右小脑后叶的CBF降低（CPL）。在mTBI患者中，CBF变化与认知障碍之间存在显着相关性。重要的是，急性mTBI患者在右CPL和右梭状回（FG）以及双侧ITG之间，左SFG和左枕中回（MOG）之间以及右SFG和右FG以及之间出现了CBF断开右海马旁回。结论。我们的结果表明，急性mTBI患者同时表现出区域性CBF异常和CBF连接缺陷，这可能是急性mTBI患者认知障碍的基础。