An alternative approach for isoprene production from readily available formaldehyde and 2-butanone under mild conditions is reported, where efficient synthesis of a nonlinear C5 1,3-diol was involved. The C5 1,3-diol was obtained over Pt-based catalysts at ≥75 °C with 93% yield, followed by dehydration affording isoprene in 73% yield.

中文翻译：

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在温和条件下由丁酮和福尔马林高效合成非线性的C5 1,3-二醇

报道了在温和条件下由易得的甲醛和2-丁酮生产异戊二烯的另一种方法，该方法涉及有效合成非线性C5 1,3-二醇。在≥75°C的情况下，在Pt基催化剂上以93％的收率获得C5 1,3-二醇，然后脱水，以73％的收率得到异戊二烯。