Local targeted “inside-out” hyperthermia of tumors via nanoparticles is able to sensitize tumor cells to chemotherapy, radiation therapy, gene therapy, immunotherapy, or other effects, significantly reducing the duration and intensity of treatment. In this article, new nanomaterials are proposed to be used as anticancer agents: boron-doped nanodiamonds with sizes of about 10 nm synthesized for the first time by the high-temperature high-pressure (HTHP) method. The heating ability of boron-doped nanodiamonds was investigated under different heating conditions in different environments: water, chicken egg white, and MCF-7 breast cancer cells. It was discovered that, with the same conversion of the absorbed energy into heat, the ability to heat the environment when excited at a wavelength of 808 nm of boron-doped nanodiamonds is much higher than that of detonation nanodiamonds. It was established that boron-doped nanodiamonds are extremely promising for carrying out hyperthermia and thermoablation of tumors.

中文翻译：

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硼掺杂纳米金刚石作为抗癌剂：进入热疗/热消融治疗的途中

通过纳米粒子局部靶向的“由内而外”的肿瘤热疗能够使肿瘤细胞对化学疗法，放射疗法，基因疗法，免疫疗法或其他作用敏感，从而显着减少了治疗的持续时间和强度。在本文中，提出了一种新型的纳米材料作为抗癌剂：高温高压（HTHP）方法首次合成了尺寸约10 nm的掺硼纳米金刚石。在不同的加热条件下，在不同的环境（水，鸡蛋白和MCF-7乳腺癌细胞）中研究了掺硼纳米金刚石的加热能力。发现在吸收能量转化为热量的情况下，在掺硼纳米金刚石的808 nm波长激发时，加热环境的能力远高于爆轰纳米金刚石。已经确定，掺硼纳米金刚石在进行肿瘤的热疗和热消融方面极有希望。