ABSTRACT

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common dementia among the elderly. The pathophysiology of AD is characterized by two hallmarks: amyloid plaques, produced by amyloid β (Aβ) aggregation, and neurofibrillary tangle (NFT), produced by accumulation of phosphorylated tau. The regulatory roles of non-coding RNAs (ncRNAs), particularly long noncoding RNAs (lncRNAs), have been widely recognized in gene expression at the transcriptional and posttranscriptional levels. Mounting evidence shows that lncRNAs are aberrantly expressed in AD progression. Here, we review the lncRNAs that implicated in the regulation of Aβ peptide, tau, inflammation, cell death, and other aspects which are the main mechanisms of AD pathology. We also discuss the possible clinical or therapeutic utility of lncRNA detection or targeting to help diagnose or possibly combat AD.

摘要

阿尔茨海默病（AD）是一种进行性神经退行性疾病，也是老年人中最常见的痴呆症。AD 的病理生理学有两个特征：淀粉样斑块（由 β 淀粉样蛋白 (Aβ) 聚集产生）和神经原纤维缠结 (NFT)（由磷酸化 tau 蛋白积累产生）。非编码RNA (ncRNA)，特别是长非编码RNA (lncRNA)，在转录和转录后水平的基因表达中的调节作用已得到广泛认可。越来越多的证据表明，lncRNA 在 AD 进展过程中异常表达。在此，我们综述了参与 Aβ 肽、tau、炎症、细胞死亡等 AD 病理主要机制调控的 lncRNA。我们还讨论了 lncRNA 检测或靶向的可能临床或治疗效用，以帮助诊断或可能对抗 AD。