ABSTRACT

Introduction

The association between interleukin(IL)-17A and IL-17 F gene polymorphism with rheumatoid arthritis (RA) were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17 F gene polymorphism with RA.

Methods

We searched Medline up to February 2020. Meta-analyses were performed for the comparisons of allele and multiple genetic models, including dominant, recessive, heterozygous, and homozygous models using fixed or random effects models. Odds ratios (OR) with 95% confidence intervals (95%CI) were utilized to assess the potential relationship.

Results

A total of 2315 confirmed cases and 2342 controls were included from eligible 10 case–controls studies. Meta analysis suggested that rs2275913 G allele increased the risk of RA in Caucasians (G vs A: OR = 1.14, 95% CI = 1.00–1.29, P = .044), but not in Mongolians (P > .05). Pooled analysis suggested that a significant associations between rs763780 C allele with RA susceptibility (C vs T: OR = 1.83, 95% CI = 1.13–2.97, P = .014). Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to RA risk in two races (P < .001). TSA plot revealed that the present study sufficient to draw a conclusion.

Conclusions

This meta-analysis demonstrates IL-17A and IL-17 F genes play a significant role in RA, but its role in Mongolian populations needs further exploration.

中文翻译：

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类风湿关节炎中白细胞介素17基因多态性（Rs2275913 G/A，Rs763780 C/T）：基于种族的Meta分析

摘要

介绍

白细胞介素（IL）-17A和IL-  17F基因多态性与类风湿性关节炎（RA）之间的关联在以往的研究中不一致。该荟萃分析旨在确定IL-17 A 和IL-17  F 基因多态性与 RA之间的关联。

方法

我们检索了截至 2020 年 2 月的 Medline。使用固定或随机效应模型对等位基因和多个遗传模型进行了荟萃分析，包括显性、隐性、杂合和纯合模型。优势比 (OR) 与 95% 置信区间 (95%CI) 用于评估潜在关系。

结果

符合条件的 10 项病例对照研究共包括 2315 例确诊病例和 2342 例对照。Meta 分析表明 rs2275913 G 等位基因增加了白种人的 RA 风险（G vs A：OR = 1.14，95 % CI = 1.00–1.29，P = .044），但在蒙古人中没有（P > .05）。汇总分析表明 rs763780 C 等位基因与 RA 易感性之间存在显着关联（C vs T：OR = 1.83，95% CI = 1.13–2.97，P = .014）。按种族进行的亚组分析表明，rs763780 C 等位基因与两个种族的 RA 风险密切相关 ( P < .001)。TSA 图显示，目前的研究足以得出一个结论。

结论

该荟萃分析表明IL-17 A 和IL-17  F 基因在 RA 中发挥重要作用，但其在蒙古人群中的作用需要进一步探索。