The aim of the study was to make a comparative studies on the effectiveness of platelet rich plasma (PRP) and hyaluronic acid (HA) in intra-articular injections to the temporomandibular joints—in double blind studies application—based on the analysis of selected clinical parameters of functional efficiency and the mean value of joint’s pain intensity before and after management. The study enrolled a group of 100 patients, aged 21 to 43 years, of both sexes, who came for the prosthodontic treatment. All patients had II b group of disorder according to the Research Diagnostic Criteria/Temporomandibular Disorder, and were consecutively, alternately assigned to the groups, 50 patients in each. Study group PRP was treated with intra-articular injection of platelet rich plasma and study group HA had injection with hyaluronic acid. The examination was double-blind, so that the injecting physician and the patient were not informed what kind of medicinal substance they received in the joint injection. The final selected clinical parameters did not differ statistically significantly between the groups, what means that both administered substances were effective in the repair of intra-articular structures. The results of research showed that the use of PRP and HA in intraarticular joint’s injections positively affects in selected clinical parameters and decrease of the pain in temporomandibular joints in the case of disc displacement without reduction.

中文翻译：

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关节内注射在不减少椎间盘移位的后果管理中的应用。

该研究的目的是在对双盲研究应用的基础上，对选定的临床分析进行富血小板血浆（PRP）和透明质酸（HA）在颞下颌关节的关节内注射中的有效性的比较研究。治疗前后的功能效率参数和关节疼痛强度平均值 该研究招募了100名年龄在21至43岁之间的男女患者，他们接受了修复治疗。根据研究诊断标准/颞下颌关节疾病，所有患者均患有II b组疾病，并连续，交替地分为两组，每组50名患者。研究组PRP关节内注射富含血小板的血浆，研究组HA注射透明质酸。检查是双盲的，因此不会告知注射医生和患者在联合注射中接受了哪种药物。最终选择的临床参数在两组之间无统计学差异，这意味着两种给药物质均能有效修复关节内结构。研究结果表明，在椎间盘移位而无复位的情况下，在关节内注射中使用PRP和HA积极影响选定的临床参数并减轻颞下颌关节的疼痛。最终选择的临床参数在两组之间无统计学差异，这意味着两种给药物质均能有效修复关节内结构。研究结果表明，在椎间盘移位而无复位的情况下，在关节内注射中使用PRP和HA积极影响选定的临床参数并减轻颞下颌关节的疼痛。最终选择的临床参数在两组之间无统计学差异，这意味着两种给药物质均能有效修复关节内结构。研究结果表明，在椎间盘移位而无复位的情况下，在关节内注射中使用PRP和HA积极影响选定的临床参数并减轻颞下颌关节的疼痛。