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Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains
FEBS Letters ( IF 3.5 ) Pub Date : 2020-07-14 , DOI: 10.1002/1873-3468.13875
Mamiko Masutani 1 , Shunya Sakurai 1 , Toshiyuki Shimizu 1 , Umeharu Ohto 1
Affiliation  

Testis‐expressed gene 101 (TEX101) is a glycosyl‐phosphatidylinositol‐anchored glycoprotein essential for sperm fertility and spermatogenesis. TEX101 interacts with lymphocyte antigen 6 complex, locus K (Ly6k) as well as a disintegrin and metallopeptidase domain 3 (ADAM3). Although these proteins are considered essential for fertility, the associated mechanisms remain uncharacterized. Herein, we determined the crystal structure of human and mouse TEX101, revealing that TEX101 contains two tandem Ly6/uPAR (LU) domains. Detailed structural analyses revealed characteristic surfaces of TEX101 that may be involved in the interactions with other proteins or membranes. These results provide the structural basis for the role of TEX101 in fertilization and could contribute to developing diagnostic methods and treatments for infertility or developing male contraceptives.

中文翻译:

TEX101 的晶体结构,一种男性生育所必需的糖蛋白,揭示了串联排列的 Ly6/uPAR 结构域的存在

睾丸表达基因 101 (TEX101) 是一种糖基磷脂酰肌醇锚定糖蛋白,对精子生育能力和精子发生至关重要。TEX101 与淋巴细胞抗原 6 复合物、基因座 K (Ly6k) 以及去整合素和金属肽酶结构域 3 (ADAM3) 相互作用。尽管这些蛋白质被认为是生育所必需的,但相关的机制仍未得到表征。在此,我们确定了人和小鼠 TEX101 的晶体结构,揭示 TEX101 包含两个串联的 Ly6/uPAR (LU) 结构域。详细的结构分析揭示了 TEX101 的特征表面,这些表面可能涉及与其他蛋白质或膜的相互作用。
更新日期:2020-07-14
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