Accurate and timely assessment of the severity of burn is essential for the treatment of burns. Currently, although most first‐degree and third‐degree burns are easily diagnosed through visual inspection or auxiliary diagnostic methods, the second‐degree burn is still difficult to distinguish due to the ambiguity boundaries of second‐degree with first‐degree and third‐degree burns. In this study, we proposed a non‐invasive technique by combing photoacoustic imaging (PAI) and optical coherence tomography (OCT) to multi‐parameter quantitatively assess the burns. The feasibility and capacity of the dual‐mode PAT/OCT for assessing the burns was first testified by tissue‐mimicking phantom and burn wounds in mouse pinna in vivo. The further experiments conducted on the back of rats showed that the changes in skin scattering structure, vascular morphology and blood flow provided by the dual‐mode PAI/OCT system can determine distinct boundaries and depth of the burns. The experimental results prove that combined PAI/OCT as a novel method can be used to assess the severity of burn, which has the potential to diagnose the burns in clinic.

中文翻译：

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基于光声和光学相干断层扫描技术对烧伤进行定量评估。

准确及时地评估烧伤严重程度对于治疗烧伤至关重要。目前，尽管大多数一级和三级烧伤很容易通过肉眼检查或辅助诊断方法进行诊断，但是由于二级与一级和三级的模糊性界限，二级烧伤仍难以区分烧伤。在这项研究中，我们提出了一种通过结合光声成像（PAI）和光学相干断层扫描（OCT）来对烧伤进行多参数定量评估的非侵入性技术。首先，通过模拟小鼠耳廓的体模和烧伤创面来证明双模式PAT / OCT评估烧伤的可行性和能力。在大鼠背部进行的进一步实验表明，皮肤散射结构的变化，双模式PAI / OCT系统提供的血管形态和血流可以确定烧伤的界限和深度。实验结果证明，结合PAI / OCT作为一种新颖的方法可用于评估烧伤的严重程度，具有临床诊断烧伤的潜力。