Macrovesicular steatosis (MS) is a major risk factor for liver graft failure after transplantation and pathological microscopic examination of a frozen tissue section remains the gold standard for its assessment. However, the latter requires an experienced in‐house pathologist for correct and rapid diagnosis as well as specific equipment that is not always available. Smartphones, which are must‐have tools for everyone, are very suitable for incorporation into promising technology to generate moveable diagnostic tools as for telepathology. The study aims to compare the microscopic assessment of nonalcoholic fatty liver disease (NAFLD) spectrum in liver allograft biopsies by a smartphone microscopy platform (DIPLE device) to standard light microscopy. Forty‐two liver graft biopsies were evaluated in transmitted light, using an iPhone X and the microscopy platform. A significant correlation was reported between the two different approaches for graft MS assessment (Spearman's correlation coefficient: r = .93; p < .001) and for steatohepatitis feature (r = .56; p < .001; r = .45; p < .001). Based on these findings, a smartphone integrated with a cheap microscopy platform can achieve adequate accuracy in the assessment of NAFLD in liver graft and could be used as an alternative to standard light microscopy when the latter is unavailable.

中文翻译：

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通过智能手机平台准确评估肝脏同种异体移植活检中的非酒精性脂肪肝疾病病变：概念验证。

大泡脂肪变性（MS）是移植后肝移植失败的主要危险因素，冷冻组织切片的病理显微镜检查仍是评估的金标准。但是，后者需要经验丰富的内部病理学家进行正确和快速的诊断，以及不总是可用的特定设备。智能手机是每个人的必备工具，非常适合融入有前途的技术中，以生成可用于远程病理学的可移动诊断工具。这项研究旨在通过智能手机显微镜平台（DIPLE设备）与标准光学显微镜比较在肝脏同种异体移植活检中非酒精性脂肪肝疾病（NAFLD）光谱的显微镜评估。在透射光下评估了42例肝移植活检，使用iPhone X和显微镜平台。两种不同的移植MS评估方法之间存在显着相关性（Spearman相关系数：r = 0.93；p  <.001）和脂肪性肝炎特征（r = .56; p  <.001; r = .45; p  <.001）。基于这些发现，集成了廉价显微镜平台的智能手机可以在评估肝移植物中的NAFLD时达到足够的准确性，并且在无法使用标准光学显微镜时，可以用作标准光学显微镜的替代品。