当前位置: X-MOL 学术J. Biomed. Mater. Res. Part A › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Biomimetic trace metals improve bone regenerative properties of calcium phosphate bioceramics
Journal of Biomedical Materials Research Part A ( IF 4.9 ) Pub Date : 2020-06-30 , DOI: 10.1002/jbm.a.37051
Alaa Mansour 1, 2 , Lina Abu Nada 1 , Amir A El-Hadad 1, 3 , Mohamed Amine Mezour 1 , Ala' Ersheidat 1, 4 , Ahmed Al-Subaie 1, 5 , Hanan Moussa 1, 6 , Marco Laurenti 7 , Mari T Kaartinen 1 , Faleh Tamimi 1, 8
Affiliation  

The bone regenerative capacity of synthetic calcium phosphates (CaPs) can be enhanced through the enrichment with selected metal trace ions. However, defining the optimal elemental composition required for bone formation is challenging due to many possible concentrations and combinations of these elements. We hypothesized that the ideal elemental composition exists in the inorganic phase of the bone extracellular matrix (ECM). To study our hypothesis, we first obtained natural hydroxyapatite through the calcination of bovine bone, which was then investigated its reactivity with acidic phosphates to produce CaP cements. Bioceramic scaffolds fabricated using these cements were assessed for their composition, properties, and in vivo regenerative performance and compared with controls. We found that natural hydroxyapatite could react with phosphoric acid to produce CaP cements with biomimetic trace metals. These cements present significantly superior in vivo bone regenerative performance compared with cements prepared using synthetic apatite. In summary, this study opens new avenues for further advancements in the field of CaP bone biomaterials by introducing a simple approach to develop biomimetic CaPs. This work also sheds light on the role of the inorganic phase of bone and its composition in defining the regenerative properties of natural bone xenografts.

中文翻译:

仿生微量金属改善磷酸钙生物陶瓷的骨再生性能

合成磷酸钙 (CaPs) 的骨再生能力可以通过富集选定的金属微量离子来增强。然而,由于这些元素的许多可能浓度和组合,确定骨形成所需的最佳元素组成具有挑战性。我们假设理想的元素组成存在于骨细胞外基质 (ECM) 的无机相中。为了研究我们的假设,我们首先通过煅烧牛骨获得天然羟基磷灰石,然后研究其与酸性磷酸盐的反应性以生产 CaP 水泥。评估了使用这些水泥制造的生物陶瓷支架的组成、特性和体内再生性能,并与对照进行了比较。我们发现天然羟基磷灰石可以与磷酸反应生成具有仿生痕量金属的 CaP 水泥。与使用合成磷灰石制备的水泥相比,这些水泥具有显着优越的体内骨再生性能。总之,本研究通过引入一种开发仿生CaPs的简单方法,为CaP骨生物材料领域的进一步发展开辟了新途径。这项工作还揭示了骨的无机相及其组成在确定天然骨异种移植物的再生特性方面的作用。这项研究通过引入一种开发仿生CaP的简单方法,为CaP骨生物材料领域的进一步发展开辟了新途径。这项工作还揭示了骨的无机相及其组成在确定天然骨异种移植物的再生特性方面的作用。这项研究通过引入一种开发仿生CaP的简单方法,为CaP骨生物材料领域的进一步发展开辟了新途径。这项工作还揭示了骨的无机相及其组成在确定天然骨异种移植物的再生特性方面的作用。
更新日期:2020-06-30
down
wechat
bug