A number of research has shown that the plant polyphenol resveratrol, one of the most prominent small molecules, has beneficial protective effects in multiple organisms, including worms, flies, and killifish. To understand the effects of resveratrol on lifespan, we evaluated its effects in the silkworm . In this study, we found that lifespan was significantly prolonged in both female and male silkworms treated with resveratrol. Silkworm larval weight was significantly increased from day 3 of the 5th larval instar (L5D3) to day 7 of the 5th larval instar (L5D7). However, the weight of the pupa, cocoon, and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in controls. Meanwhile, resveratrol significantly improved the thermotolerance of the silkworms, which enhanced their survival rate. Moreover, antioxidant activity was increased by resveratrol in both female and male silkworms. Furthermore, an antioxidant-related signalling pathway, SIRT7-FoxO-GST, was activated in silkworms with resveratrol treatment. Collectively, these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.

中文翻译：

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白藜芦醇可延长家蚕的寿命并提高其抗氧化活性

多项研究表明，植物多酚白藜芦醇是最重要的小分子之一，对多种生物体（包括蠕虫、苍蝇和鳉鱼）具有有益的保护作用。为了了解白藜芦醇对寿命的影响，我们评估了它对家蚕的影响。在这项研究中，我们发现经过白藜芦醇处理的雌性和雄性蚕的寿命均显着延长。蚕幼虫体重从5龄幼虫(L5D3)第3天到5龄幼虫(L5D7)第7天显着增加。然而，白藜芦醇处理的雌性蚕的蛹、茧和总茧的重量与对照组相比没有显着差异。同时，白藜芦醇显着提高了蚕的耐热性，从而提高了其成活率。此外，白藜芦醇可以提高雌性和雄性蚕的抗氧化活性。此外，白藜芦醇处理后的蚕体内抗氧化相关信号通路 SIRT7-FoxO-GST 被激活。总的来说，这些结果有助于我们了解白藜芦醇诱导长寿作用的分子途径，并表明蚕是评估延长寿命药物效果的有前途的动物模型。