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Adenine-coated magnetic multiwalled carbon nanotubes for the selective extraction of aristolochic acids based on multiple interactions.
Journal of Chromatography A ( IF 4.1 ) Pub Date : 2020-06-30 , DOI: 10.1016/j.chroma.2020.461382
Hua Shu 1 , Guoning Chen 1 , Lu Wang 1 , Xia Cui 1 , Qun Wang 1 , Wen Li 1 , Chun Chang 1 , Qi Guo 1 , Zhimin Luo 1 , Qiang Fu 1
Affiliation  

A method is described for the functionalization of magnetic carbon nanotubes to recognize aristolochic acid Ⅰ and Ⅱ. 3-Glycidyloxypropyltrimethoxysilane was used as a coupling agent to immobilize adenine on a solid support. The morphology and structure of adenine-coated magnetic carbon nanotubes was investigated using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and a vibrating sample magnetometer (VSM). The adsorption performance of the adenine-coated magnetic carbon nanotubes was evaluated via adsorption isotherms, the kinetics and selectivity tests. The adsorption capacity of the adenine-functionalized sorbent for aristolochic acid Ⅰ was determined to be 24.5 μg mg−1. By combining magnetic solid phase extraction with HPLC detection, a method was developed to enrich and detect aristolochic acids used in traditional Chinese medicine. A satisfactory recovery (92.7 - 97.5% for aristolochic acid Ⅰ and 92.6 - 99.4% for aristolochic acid Ⅱ) and an acceptable relative standard deviation (<4.0%) were obtained.



中文翻译:

涂有腺嘌呤的磁性多壁碳纳米管,可基于多种相互作用选择性萃取马兜铃酸。

描述了一种功能化磁性碳纳米管识别马兜铃酸Ⅰ和Ⅱ的方法。使用3-缩水甘油基氧丙基三甲氧基硅烷作为偶联剂以将腺嘌呤固定在固体载体上。使用透射电子显微镜(TEM),扫描电子显微镜(SEM),X射线衍射(XRD)和振动样品磁力计(VSM)研究了涂有腺嘌呤的磁性碳纳米管的形态和结构。通过吸附等温线,动力学和选择性测试评估了腺嘌呤包覆的磁性碳纳米管的吸附性能。经腺嘌呤官能化的吸附剂对马兜铃酸Ⅰ的吸附容量为24.5μgmg -1。通过将磁性固相萃取与HPLC检测相结合,开发了一种富集和检测中药中马兜铃酸的方法。回收率令人满意(马兜铃酸Ⅰ为92.7-97.5%,马兜铃酸Ⅱ为92.6-99.4%)和相对标准偏差可以接受(<4.0%)。

更新日期:2020-07-13
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