This study aims to calculate deposition of PM_2.5 -bound hazardous metals in different organs after inhalation of particulate matter for the Delhi (India), and to estimate risks to organs following inhalation. Bio-accessible fractions of three PM-associated carcinogenic metals (As, Pb &Cd) were calculated using the metal values in simulated lung fluids. Depositions of metals in different organs were calculated using an integrated model consists of HRT and PBPK models. The calculation indicates that the major or significant deposition of metal Pb occurs in tissues, such as bone, muscle and blood. Most of the depositions of Cd happens in lung whereas most of the depositions of As happens in lung, muscle and skin. Most of the deposition of studied metals was found in lung (45% for arsenic and 70% for cadmium of their bio -dissolved contents). The following order of depositions of metals in different tissues were found (from highest deposition to smallest deposition): As: Lung > muscle = liver; Pb: bone > blood > muscle; Cd: lung > intestine. The combined exposures of PM_2.5 and its associated metals were found to give interaction-based hazard index greater than 1 for several months of the year, indicating a chance of health risk. Hazard quotient (HQ) <1 was seen for ingestion and dermal pathways, indicating no cause of concern. Findings indicate the need for doing periodic monitoring and estimating deposition doses and exposure risks of PM-associated metals to lungs and other organs for protecting human health.

本研究旨在计算PM _2.5的沉积德里（印度）吸入颗粒物后在不同器官中吸收的有害金属，并估算吸入后对器官的危害。使用模拟肺液中的金属值计算了三种与PM相关的致癌金属（As，Pb和Cd）的生物可及分数。使用由HRT和PBPK模型组成的集成模型来计算不同器官中的金属沉积量。计算表明，金属Pb的主要或大量沉积发生在组织（例如骨骼，肌肉和血液）中。镉的大部分沉积发生在肺中，而砷的大部分沉积发生在肺，肌肉和皮肤中。被研究金属的大部分沉积物是在肺中发现的（其中45％的砷是砷，而70％的镉是其生物溶解成分）。发现金属在不同组织中的沉积顺序如下（从最高沉积到最小沉积）：As：肺>肌肉=肝脏；铅：骨骼>血液>肌肉；镉：肺>肠。PM的综合暴露在一年中的几个月中，发现_2.5及其相关金属的基于相互作用的危害指数大于1，表明存在健康风险。食入和皮肤途径的危险性商（HQ）<1。研究结果表明需要进行定期监测和估计沉积剂量以及与PM相关的金属向肺和其他器官的暴露风险，以保护人体健康。