Abstract

Mangiferin is a compound with many pharmacological activities and exists in many natural products. Anhydrous and hydrate of mangiferin have been reported separately in two literatures, but the polymorphism of this compound has not been realized until this paper. In this study, polymorph screening of mangiferin has been carried out and five forms have been obtained including three new forms never reported. Several solid state characterization methods, such as powder X-ray diffraction, differential scanning calorimetry and thermogravimetry, are used to identify and characterize all of mangiferin forms. The comparison of the crystallographic data and hirshfeld surface analysis were first reported for mangiferin anhydrous and hydrate. Furthermore, the studies on stability, transformation and solubility have been undertaken, the results prompt that form V can be used as the dominant polymorph for the development of innovative pharmaceuticals.

Graphic Abstract

中文翻译：

---

芒果苷多晶型物的筛选，表征和评价。

摘要

芒果苷是具有许多药理活性的化合物，并且存在于许多天然产物中。芒果苷的无水和水合物已在两篇文献中分别报道，但该化合物的多态性直到本文才得以实现。在这项研究中，已对芒果苷进行了多晶型物筛选，并获得了五种形式，包括三种从未报道过的新形式。几种固态表征方法，例如粉末X射线衍射，差示扫描量热法和热重分析法，用于鉴定和表征所有芒果苷形式。首先报道了芒果无水和水合物的晶体学数据比较和希尔希菲尔德表面分析。此外，还进行了稳定性，转化率和溶解度的研究，

图形摘要