This work prepared and evaluated transdermal patches for delivery of lidocaine and diclofenac. Pectin and Eudragit® NE 30 D were used as a polymer matrix, and glycerin was used as a plasticizer. A lidocaine–diclofenac ionic liquid drug was prepared by ion-pair reactions between the hydrochloride salts of lidocaine and the sodium salts of diclofenac. Characterization properties of blank films and transdermal patches such as mechanical properties, differential scanning calorimeter, thermogravimetric analysis, X-ray diffraction, and scanning electron microscope were evaluated, and the in vitro drug release was studied. It was found that the amount of Eudragit® NE 30 D and the lidocaine–diclofenac ionic liquid drug loading directly affected all characterization properties. Moreover, the crystal characteristics of the drug were found in the transdermal patches when the amount of Eudragit® NE 30 D increased. The thicknesses of the blank films and transdermal patches were in the range of 193–231 µm and 200–233 µm, respectively. The drug contents in transdermal patches were in the range of 1.88–2.11 mg/cm² and 2.33–2.64 mg/cm² for lidocaine and diclofenac, respectively. The drug release values of both lidocaine and diclofenac were controlled by the polymer matrix of the transdermal patches. However, the percentage of cumulative drug release decreased when the crystals were in the transdermal patches. In conclusion, the preparation of ionic liquid drug-based polymeric matrices for transdermal delivery of lidocaine and diclofenac provided controlled drug release and will be developed in future studies.

这项工作准备并评估了用于递送利多卡因和双氯芬酸的透皮贴剂。果胶和Eudragit NE 30 D用作聚合物基质，甘油用作增塑剂。通过利多卡因盐酸盐与双氯芬酸钠盐之间的离子对反应制备了利多卡因-双氯芬酸离子液体药物。对空白薄膜和透皮贴剂的力学性能，差示扫描量热仪，热重分析，X射线衍射和扫描电子显微镜等进行了表征，并对体外药物释放进行了研究。已发现Eudragit®NE 30 D的量和利多卡因-双氯芬酸离子液体药物的负载量直接影响所有表征特性。此外，当Eudragit®NE 30 D的量增加时，在透皮贴剂中发现了该药物的晶体特性。空白膜和透皮贴剂的厚度分别在193–231 µm和200–233 µm的范围内。透皮贴剂中的药物含量在1.88–2.11 mg / cm的范围内利多卡因和双氯芬酸分别为²和2.33–2.64 mg / cm ²。利多卡因和双氯芬酸的药物释放值均由透皮贴剂的聚合物基质控制。然而，当晶体在透皮贴剂中时，累积药物释放的百分比降低。总之，用于利多卡因和双氯芬酸透皮递送的基于离子液体药物的聚合物基质的制备提供了可控的药物释放，并将在未来的研究中得到发展。