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Standardizing luminescence nanothermometry for biomedical applications.
Nanoscale ( IF 6.7 ) Pub Date : 2020-06-30 , DOI: 10.1039/d0nr03568h
Artur Bednarkiewicz 1 , Lukasz Marciniak 1 , Luís D Carlos 2 , Daniel Jaque 3
Affiliation  

Luminescence nanothermometry enables accurate, remote, and all-optically-based thermal sensing. Notwithstanding its fast development, there are serious obstacles hindering reproducibility and reliable quantitative assessment of nanothermometers, which impede the intentional design, optimization and use of these sensors. These issues include ambiguities or absence of established universal rules for quantitative evaluation, incorrect assumptions about the mechanisms behind the thermal response of the sensors as well as the dependence of the nanothermometers readout on external conditions and host materials themselves. In this perspective article, we discuss these problems and propose a series of standardization guidelines to be followed. This critical discourse constitutes the first required step towards the ubiquitous acceptance, by the scientific community, of luminescence thermometry as a reliable tool for remote temperature determination in numerous practical biomedical implementations.

中文翻译:

用于生物医学应用的标准化发光纳米温度计。

发光纳米温度计可实现精确,远程和全光学的热感应。尽管其发展很快,但是仍然存在严重的障碍,阻碍了纳米温度计的可重复性和可靠的定量评估,这阻碍了这些传感器的故意设计,优化和使用。这些问题包括不确定性或没有建立定量评估的通用规则,对传感器热响应背后的机制的错误假设以及纳米温度计的读数对外部条件和主体材料本身的依赖性。在这篇观点文章中,我们讨论了这些问题,并提出了一系列要遵循的标准化指南。这种批判性的话语是迈向普遍接受的第一步,
更新日期:2020-07-16
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