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Periodontal Disease and Periodontal Disease-Related Bacteria Involved in the Pathogenesis of Alzheimer's Disease.
Journal of Inflammation Research ( IF 4.5 ) Pub Date : 2020-06-30 , DOI: 10.2147/jir.s255309
Kenji Matsushita 1 , Masae Yamada-Furukawa 1 , Mie Kurosawa 1 , Yosuke Shikama 1
Affiliation  

Abstract: Alzheimer’s disease (AD) is the most common cause of dementia, and it exhibits pathological properties such as deposition of extracellular amyloid β (Aβ) and abnormally phosphorylated Tau in nerve cells and a decrease of synapses. Conventionally, drugs targeting Aβ and its related molecules have been developed on the basis of the amyloid cascade hypothesis, but sufficient effects on the disease have not been obtained in past clinical trials. On the other hand, it has been pointed out that chronic inflammation and microbial infection in the brain may be involved in the pathogenesis of AD. Recently, attention has been focused on the relationship between the periodontopathic bacterium Porphylomonas gingivalis and AD. P. gingivalis and its toxins have been detected in autopsy brain tissues from patients with AD. In addition, pathological conditions of AD are formed or exacerbated in mice infected with P. gingivalis. Compounds that target the toxins of P. gingivalis ameliorate the pathogenesis of AD triggered by P. gingivalis infection. These findings indicate that the pathological condition of AD may be regulated by controlling the bacteria in the oral cavity and the body. In the current aging society, the importance of oral and periodontal care for preventing the onset of AD will increase.

Keywords: Porphylomonas gingivalis, cognitive decline, amyloid β, blood-brain barrier, vascular inflammation


中文翻译:

牙周病和与牙周病相关的细菌参与了阿尔茨海默氏病的发病机理。

摘要:阿尔茨海默氏病(AD)是痴呆症最常见的病因,它具有病理性质,例如神经细胞中细胞外淀粉样β(Aβ)沉积和磷酸化Tau异常以及突触减少。常规地,已经基于淀粉样蛋白级联假说开发了靶向Aβ及其相关分子的药物,但是在过去的临床试验中尚未获得对该疾病的足够效果。另一方面,已经指出,脑中的慢性炎症和微生物感染可能与AD的发病机理有关。最近,注意力集中在牙周病菌牙龈卟啉单胞菌和AD之间的关系。牙龈卟啉单胞菌其毒素已在AD患者的尸检脑组织中被检测到。另外,在感染牙龈卟啉单胞菌的小鼠中AD的病理状况形成或加剧。靶向牙龈卟啉单胞毒素的化合物改善了由牙龈卟啉单感染触发的AD的发病机理。这些发现表明,AD的病理状况可以通过控制口腔和身体中的细​​菌来调节。在当前的老龄化社会中,口腔和牙周护理对于预防AD发病的重要性将会增加。

关键词: 牙龈卟啉单胞菌认知能力下降β淀粉样蛋白血脑屏障血管炎症
更新日期:2020-06-30
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