Isolation of 2-Alkyl-4-quinolones with Unusual Side Chains from a Chinese Pseudomonas aeruginosa Isolate.,Journal of Natural Products

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Isolation of 2-Alkyl-4-quinolones with Unusual Side Chains from a Chinese Pseudomonas aeruginosa Isolate.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2020-06-30 , DOI: 10.1021/acs.jnatprod.0c00026
Jianye Li ₁ , Weiwei Sun ₁ , Muhammad Saalim ₁ , Guixiang Wei ₁ , Diana A Zaleta-Pinet ₁ , Benjamin R Clark ₁

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Chemical investigation of a Pseudomonas aeruginosa strain isolated from Hebei, China, led to the isolation of a suite of quinolones, quinolone-N-oxides, and phenazines, the structures of which were elucidated by detailed spectroscopic analysis. Most notable among the secondary metabolites isolated was an unprecedented 4-quinolone containing an S-methyl group in the side chain and a new derivative including a phenyl ring in the side chain, which expand significantly the variety of structural motifs found in the quinolones and raise interesting questions about their biosynthesis.

更新日期：2020-07-24

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