Circular RNAs (circRNAs), as a recently established group of endogenous noncoding RNAs, have been involved in the occurrence and development of different malignancies. Gastric cancer (GC) remains a globally significant contributor to death in cancer patients due to insufficient early diagnosis, limited treatment measures, and poor prognosis. An increasing number of studies have found that many circRNAs are dysregulated in GC and are closely associated with its tumorigenesis and metastasis. Thus, circRNAs have the potential to serve as diagnostic and prognostic biomarkers and even therapeutic targets. This review comprehensively summarizes the most recent findings on how circRNAs influence GC progression and their clinical value. In addition, we present several methological deficiencies in the studies and provide some promising ideas for future research.

中文翻译：

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胃癌中的环状RNA：潜在的生物标志物和治疗靶标。

环状RNA（circRNA）作为最近建立的一组内源性非编码RNA，已经参与了不同恶性肿瘤的发生和发展。由于早期诊断不足，治疗措施有限和预后不良，胃癌（GC）仍然是导致癌症患者死亡的全球重要因素。越来越多的研究发现，许多circRNA在GC中失调，并且与其肿瘤发生和转移密切相关。因此，circRNA具有用作诊断和预后生物标志物甚至治疗靶标的潜力。这篇综述全面总结了关于circRNA如何影响GC进展及其临床价值的最新发现。此外，