We performed a retrospective study of Covid-19 in people with HIV (PWH). PWH with Covid-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin-6, interleukin-8, and TNF-alpha were commonly elevated. In all, 19/72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of Covid-19 despite ART and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.

中文翻译：

---

HIV 感染者 Covid-19 的临床结果和免疫学特征。

我们对 HIV 感染者 (PWH) 进行了一项关于 Covid-19 的回顾性研究。患有 Covid-19 的感染者表现出严重的淋巴细胞减少和 CD4+ T 细胞计数减少。炎症标志物（包括 C 反应蛋白、纤维蛋白原、D-二聚体、白细胞介素 6、白细胞介素 8 和 TNF-α）的水平普遍升高。总共有 19/72 名住院患者 (26.4%) 死亡，53 人 (73.6%) 康复。死亡的感染者比康复者有更高水平的炎症标志物和更严重的淋巴细胞减少症。这些发现表明，尽管接受了抗逆转录病毒治疗，感染者仍面临出现严重 Covid-19 症状的风险，而那些炎症标志物增加和免疫失调的人则面临着更糟糕结果的风险。