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FastpH-mediated changes of the viscosity of protein solutions studied with a voltage-modulated quartz crystal microbalance
Biointerphases ( IF 2.1 ) Pub Date : 2020-03-24 , DOI: 10.1116/1.5140619
Alexander Gödde 1 , Christian Leppin 1 , Frederick S. Meyer 1 , Arne Langhoff 1 , Josef Hartl 2 , Patrick Garidel 2 , Diethelm Johannsmann 1
Affiliation  

An electrochemical quartz crystal microbalance is described, which achieves a time resolution down to 100 μs. Accumulation and averaging over a few hours bring the noise down to about 30 mHz. The application examples are pH-driven viscosity changes in albumin solutions. The pH was switched with the electrode potential. The characteristic response time is in the millisecond range. The focus is on experimental aspects as well as advantages and limitations of the technique.

中文翻译:

用pH调节的石英晶体微量天平研究pH介导的蛋白质溶液粘度的快速pH变化

电化学石英晶体微天平中描述,其实现了时间分辨率下降到100个 μ秒。几个小时的积累和平均会将噪声降低到大约30 mHz。应用程序的例子是p在白蛋白溶液H-从动粘度变化。所述p H为与所述电极电势切换。特征响应时间在毫秒范围内。重点是实验方面以及该技术的优点和局限性。
更新日期:2020-03-24
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