We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n = 46,350), attention deficit hyperactivity disorder (ADHD) (n = 55,374), and depression (DEP) (n = 688,809). After the meta-analysis, the number of genomic loci increased from 14 to 19 in ADHD, from 3 to 10 in ASD, from 45 to 57 in DEP, from 8 to 54 in BD, and from 64 to 87 in SCZ. We observed significant enrichment of overlapping genes among different disorders and identified a panel of cross-disorder genes. A total of seven genes were found being commonly associated with four out of five psychiatric conditions, namely GABBR1, GLT8D1, HIST1H1B, HIST1H2BN, HIST1H4L, KCNB1, and DCC. The SORCS3 gene was highlighted due to the fact that it was involved in all the five conditions of study. Analysis of correlations unveiled the existence of two clusters of related psychiatric conditions, SCZ and BD that were separate from the other three traits, and formed another group. Our results may provide a new insight for genetic basis of the five psychiatric disorders.

我们对精神分裂症（SCZ）（ n  = 65,967）、双向情感障碍（BD）（n  = 41,653）、自闭症谱系障碍（ASD）（n  = 46,350）、注意力进行了全基因组关联研究的跨性状荟萃分析缺陷多动障碍 (ADHD) ( n  = 55,374) 和抑郁症 (DEP) ( n  = 688,809)。荟萃分析后，ADHD的基因组位点数量从14个增加到19个，ASD的基因组位点数量从3个增加到10个，DEP的基因组位点数量从45个增加到57个，BD的基因组位点数量从8个增加到54个，SCZ的基因组位点数量从64个增加到87个。我们观察到不同疾病之间重叠基因的显着富集，并鉴定了一组跨疾病基因。总共发现了七个基因通常与五分之四的精神疾病相关，即GABBR1、GLT8D1、HIST1H1B、HIST1H2BN、HIST1H4L、KCNB1和DCC。SORCS3 基因之所以受到关注，是因为它参与了所有五种研究条件。相关性分析揭示了两组相关精神疾病的存在，即 SCZ 和 BD，它们与其他三个特征分开，并形成了另一组。我们的结果可能为五种精神疾病的遗传基础提供新的见解。