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Tricalcium Phosphate Sol-Incorporated Poly(ε-caprolactone) Membrane with Improved Mechanical and Osteoinductive Activity as an Artificial Periosteum
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2020-06-30 , DOI: 10.1021/acsbiomaterials.0c00511 Laijun Liu 1, 2 , Chaojing Li 1 , Xingxing Liu 1 , Yongjie Jiao 1 , Fujun Wang 1, 2 , Guansen Jiang 3 , Lu Wang 1
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2020-06-30 , DOI: 10.1021/acsbiomaterials.0c00511 Laijun Liu 1, 2 , Chaojing Li 1 , Xingxing Liu 1 , Yongjie Jiao 1 , Fujun Wang 1, 2 , Guansen Jiang 3 , Lu Wang 1
Affiliation
The periosteum plays a very important role in bone remodeling and regeneration due to its excellent osteogenic ability. However, in bone defects, the periosteum is inevitably damaged, has poor self-repair ability, and requires artificial materials as a substitute. This study is aimed to fabricate a highly bioactive poly(ε-caprolactone)/tricalcium phosphate sol (PCL/TCP sol) hybrid membrane as an artificial periosteum covering the surface of the bone defect to enhance bone regeneration. Three kinds of PCL membranes with different TCP contents were prepared and marked as P20T1 (4.8 wt %), P10T1 (9.1 wt %), and P5T1 (16.7 wt %). The physicochemical properties’ evaluation confirmed that TCP sol was homogeneously dispersed in the PCL nanofibers. Compared with P5T1, samples P10T1 and P20T1 had enhanced the mechanical properties and a moderately hydrophilic surface (67.3 ± 2.4° for P20T1 and 48.9 ± 4.1° for P10T1). The biomineralization of hybrid membranes was significantly improved compared to the PCL membrane. Moreover, hybrid membranes significantly upregulated the rat bone marrow mesenchymal stem cells’ (rBMSCs) response (proliferation and osteogenic differentiation) to them, and P10T1 showed better surface properties (hydrophilicity, bioactivity, and biomineralization) than P20T1. Thus, sample P10T1 with the best properties in this study has great potential as an artificial periosteum to accelerate bone regeneration.
中文翻译:
磷酸三钙溶胶结合的聚(ε-己内酯)膜具有改善的机械和成骨活性,作为人工骨膜
骨膜由于其优异的成骨能力,在骨重塑和再生中起着非常重要的作用。但是,在骨缺损中,骨膜不可避免地受到损伤,自我修复能力差,并且需要人造材料来替代。这项研究旨在制造具有高生物活性的聚(ε-己内酯)/磷酸三钙溶胶(PCL / TCP sol)杂化膜,作为覆盖骨缺损表面的人工骨膜,以增强骨再生。制备了三种具有不同TCP含量的PCL膜,分别标记为P20T1(4.8 wt%),P10T1(9.1 wt%)和P5T1(16.7 wt%)。物理化学性质的评估证实TCP溶胶均匀地分散在PCL纳米纤维中。与P5T1相比,样品P10T1和P20T1具有增强的机械性能和中等亲水性的表面(P20T1为67.3±2.4°,P10T1为48.9±4.1°)。与PCL膜相比,杂化膜的生物矿化显着改善。此外,杂合膜显着上调了大鼠骨髓间充质干细胞(rBMSC)对它们的反应(增殖和成骨分化),并且P10T1显示出比P20T1更好的表面性质(亲水性,生物活性和生物矿化)。因此,在这项研究中具有最佳性能的样品P10T1作为加速骨再生的人造骨膜具有巨大潜力。杂合膜显着上调了大鼠骨髓间充质干细胞(rBMSCs)对它们的反应(增殖和成骨分化),并且P10T1显示出比P20T1更好的表面特性(亲水性,生物活性和生物矿化)。因此,在这项研究中具有最佳性能的样品P10T1作为加速骨再生的人造骨膜具有巨大潜力。杂合膜显着上调了大鼠骨髓间充质干细胞(rBMSCs)对它们的反应(增殖和成骨分化),并且P10T1显示出比P20T1更好的表面特性(亲水性,生物活性和生物矿化)。因此,在这项研究中具有最佳性能的样品P10T1作为加速骨再生的人造骨膜具有巨大潜力。
更新日期:2020-08-10
中文翻译:
磷酸三钙溶胶结合的聚(ε-己内酯)膜具有改善的机械和成骨活性,作为人工骨膜
骨膜由于其优异的成骨能力,在骨重塑和再生中起着非常重要的作用。但是,在骨缺损中,骨膜不可避免地受到损伤,自我修复能力差,并且需要人造材料来替代。这项研究旨在制造具有高生物活性的聚(ε-己内酯)/磷酸三钙溶胶(PCL / TCP sol)杂化膜,作为覆盖骨缺损表面的人工骨膜,以增强骨再生。制备了三种具有不同TCP含量的PCL膜,分别标记为P20T1(4.8 wt%),P10T1(9.1 wt%)和P5T1(16.7 wt%)。物理化学性质的评估证实TCP溶胶均匀地分散在PCL纳米纤维中。与P5T1相比,样品P10T1和P20T1具有增强的机械性能和中等亲水性的表面(P20T1为67.3±2.4°,P10T1为48.9±4.1°)。与PCL膜相比,杂化膜的生物矿化显着改善。此外,杂合膜显着上调了大鼠骨髓间充质干细胞(rBMSC)对它们的反应(增殖和成骨分化),并且P10T1显示出比P20T1更好的表面性质(亲水性,生物活性和生物矿化)。因此,在这项研究中具有最佳性能的样品P10T1作为加速骨再生的人造骨膜具有巨大潜力。杂合膜显着上调了大鼠骨髓间充质干细胞(rBMSCs)对它们的反应(增殖和成骨分化),并且P10T1显示出比P20T1更好的表面特性(亲水性,生物活性和生物矿化)。因此,在这项研究中具有最佳性能的样品P10T1作为加速骨再生的人造骨膜具有巨大潜力。杂合膜显着上调了大鼠骨髓间充质干细胞(rBMSCs)对它们的反应(增殖和成骨分化),并且P10T1显示出比P20T1更好的表面特性(亲水性,生物活性和生物矿化)。因此,在这项研究中具有最佳性能的样品P10T1作为加速骨再生的人造骨膜具有巨大潜力。