Allostatic load (AL) is the manifestation of cumulative responses to chronic stress exposure. Numerous studies have shown the importance of AL in understanding disease risks. Yet little is known about existing interventions that target AL specifically. We aimed to address this gap by identifying interventions targeting AL and determining the success of these interventions in improving biological functioning. We searched five electronic databases using variations of two concepts: AL and programs or interventions. We included original research reports that focused on AL as an outcome. We excluded work that focused on a single indicator, not written in English or did not implement an intervention. The Template for Intervention Description and Replication checklist guided our intervention critique and synthesis. Six articles were included, with sample size across the interventions ranging between 2 and 733. Despite inconsistencies in the selection of AL indicators and scoring of AL, all four body systems were represented in all the studies. Four interventions showed significant improvement in Al (as indicated by a decrease in AL score) as early as 7 weeks. More interventions targeting Al are needed. The reduction in AL scores among four of the six interventions suggests that Al could be a biological outcome measure that is sensitive to change in response to interventions. This has significant clinical and research implications. Future studies are needed to examine whether AL serves as a mediator in the effects of the intervention on improving clinical manifestations of diseases.

静态负荷 (AL) 是对慢性压力暴露的累积反应的表现。许多研究表明 AL 在了解疾病风险方面的重要性。然而，对专门针对 AL 的现有干预措施知之甚少。我们旨在通过确定针对 AL 的干预措施并确定这些干预措施在改善生物功能方面是否成功来解决这一差距。我们使用两个概念的变体搜索了五个电子数据库：AL 和程序或干预。我们纳入了以 AL 作为结果的原始研究报告。我们排除了专注于单一指标的工作，而不是用英文写的或没有实施干预的工作。干预描述和复制清单模板指导了我们的干预批评和综合。收录了六篇文章，干预的样本量介于 2 到 733 之间。尽管 AL 指标的选择和 AL 评分不一致，但所有研究中都代表了所有四个身体系统。早在 7 岁，四项干预措施就显示出 Al 的显着改善（如 AL 评分下降所示） 周。需要更多针对 Al 的干预措施。六项干预措施中的四项干预措施的 AL 分数降低表明，Al 可能是一种生物学结果衡量指标，对干预措施的反应变化很敏感。这具有重要的临床和研究意义。未来的研究需要检查 AL 是否在干预对改善疾病临床表现的影响中起中介作用。