Super-enhancers (SEs) are a large cluster of cis-regulatory DNA elements that contain many binding motifs, which master transcription factors and cofactors bind to with high density. SEs usually regulate the expression of genes that can control the cell identity and fate, and SEs can be used to explain the patterns of the expression of cell-specific genes. Hence, it shows great potential for application in the treatment of diseases like cancer. At present, the clinical treatments for osteosarcoma, Ewing sarcoma, and other bone-related diseases remain challenging. The poor prognosis and difficult treatment of these diseases imposes heavy economic burden on patients and society. In recent years, research on SEs with respect to bone-related diseases has attracted increasing attention. In this paper, we first review the identification and functional mechanisms of SEs. Then, we integrate the findings of the emerging studies on SEs in bone-related diseases. Finally, we summarize recent strategies for targeting SEs for the treatment of bone-related diseases. This review aims to provide comprehensive insights into the roles of SEs in bone-related diseases.

超级增强器（SE）是由 顺式-调控性DNA元素，包含许多结合基序，可控制转录因子和辅因子以高密度结合。SEs通常调节可控制细胞身份和命运的基因的表达，SEs可用于解释细胞特异性基因表达的模式。因此，它显示出在治疗诸如癌症的疾病中的巨大潜力。目前，骨肉瘤，尤因肉瘤和其他骨相关疾病的临床治疗仍然具有挑战性。这些疾病的预后不良和治疗困难给患者和社会带来沉重的经济负担。近年来，关于与骨相关疾病有关的SEs的研究已引起越来越多的关注。在本文中，我们首先回顾SE的识别和功能机制。然后，我们整合了有关骨相关疾病中SE的新兴研究结果。最后，我们总结了针对SEs治疗骨相关疾病的最新策略。本文旨在就SE在骨骼相关疾病中的作用提供全面的见解。