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A Moving Residual Limb: Botulinum Toxin to the Rescue
Translational Neuroscience ( IF 2.1 ) Pub Date : 2020-02-29 , DOI: 10.1515/tnsci-2020-0006
Marie-Michèle Briand 1 , Mathieu Boudier-Réveret 2 , Xavier Rodrigue 1 , Geneviève Sirois 1 , Min Cheol Chang 3
Affiliation  

Movement disorders post-amputation are a rare complication and can manifest as the jumping stump phenomenon, a form of peripheral myoclonus. The pathophysiology remains unknown and there is currently no standardized treatment. We describe the case of a 57-year-old male with unremitting stump myoclonus, starting one month after transtibial amputation, in his residual limb without associated phantom or neurological pain. The consequence of the myoclonus was a reduction in prosthetic wearing time. Failure to respond to oral medication led us to attempt the use of botulinum neurotoxin Type A injections in the involved muscles of the residual limb. Injection trials, over a two-year period, resulted in an improvement of movement disorder, an increased prosthetic wearing time and a higher satisfaction level of the patient. Injection of botulinum toxin type A should be considered as an alternative treatment for stump myoclonus to improve prosthetic wearing time and comfort.

中文翻译:

移动的残留肢体:肉毒杆菌毒素的抢救

截肢后运动障碍是一种罕见的并发症,可以表现为跳跃性残端现象,一种周围性肌阵挛。病理生理学仍然未知,目前没有标准化的治疗方法。我们描述了一个57岁的男性患者的病例,该男性患者的残肢无残余残端肌阵挛,开始于经胫骨截肢后一个月,没有相关的幻像或神经痛。肌阵挛的后果是减少了假肢佩戴时间。对口服药物的反应失败导致我们尝试在残留肢体的受累肌肉中使用A型肉毒杆菌神经毒素注射剂。经过两年的注射试验,运动障碍得到改善,假肢佩戴时间增加,患者满意度更高。
更新日期:2020-02-29
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