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Analysis and Testing of a Suitable Compatible Electrode's Material for Continuous Measurement of Glucose Concentration.
Sensors ( IF 3.9 ) Pub Date : 2020-06-30 , DOI: 10.3390/s20133666
Nikola Slaninova 1 , Klara Fiedorova 1 , Ali Selamat 2, 3 , Karolina Danisova 1 , Jan Kubicek 1 , Ewaryst Tkacz 4 , Martin Augustynek 1
Affiliation  

The subject of the submitted work is the proposal of electrodes for the continual measurement of the glucose concentration for the purpose of specifying further hemodynamic parameters. The proposal includes the design of the electronic measuring system, the construction of the electrodes themselves and the functionality of the entire system, verified experimentally using various electrode materials. The proposed circuit works on the basis of micro-ammeter measuring the size of the flowing electric current and the electrochemical measurement method is used for specifying the glucose concentration. The electrode system is comprised of two electrodes embedded in a silicon tube. The solution consists of the measurement with three types of materials, which are verified by using three solutions with a precisely given concentration of glucose in the form of a mixed solution and enzyme glucose oxidase. For the testing of the proposed circuit and the selection of a suitable material, the testing did not take place on measurements in whole blood. For the construction of the electrodes, the three most frequently used materials for the construction of electrodes used in clinical practice for sensing biopotentials, specifically the materials Ag/AgCl, Cu and Au, were used. The performed experiments showed that the material Ag/AgCl, which had the greatest sensitivity for the measurement even without the enzyme, was the most suitable material for the electrode. This conclusion is supported by the performed statistical analysis. On the basis of the testing, we can come to the conclusion that even if the Ag/AgCl electrode appears to be the most suitable, showing high stability, gold-plated electrodes showed stability throughout the measurement similarly to Ag/AgCl electrodes, but did not achieve the same qualities in sensitivity and readability of the measured results.

中文翻译:

分析和测试适用于连续测量葡萄糖浓度的兼容电极材料。

提交的工作的主题是电极的建议,用于连续测量葡萄糖浓度,以指定更多的血液动力学参数。该提议包括电子测量系统的设计,电极本身的结构以及整个系统的功能,这些功能已使用各种电极材料进行了实验验证。所提出的电路是在微电流表测量流动电流大小的基础上进行的,并且电化学测量方法用于指定葡萄糖浓度。电极系统由嵌入硅管中的两个电极组成。该解决方案包括三种材料的测量,可以通过使用三种浓度精确确定的葡萄糖溶液(以混合溶液和葡萄糖氧化酶的形式)进行验证。为了测试所建议的电路并选择合适的材料,并未在全血中进行测试。对于电极的构造,使用在临床实践中用于感测生物电势的电极的三种最常用的材料,特别是材料Ag / AgCl,Cu和Au。进行的实验表明,即使没有酶也对测量具有最高灵敏度的材料Ag / AgCl是最适合电极的材料。该结论得到进行的统计分析的支持。根据测试,
更新日期:2020-06-30
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