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Recent Advances in the Electrochemical Sensing of Venlafaxine: An Antidepressant Drug and Environmental Contaminant.
Sensors ( IF 3.9 ) Pub Date : 2020-06-30 , DOI: 10.3390/s20133675
Somayeh Tajik 1 , Hadi Beitollahi 2 , Zahra Dourandish 2 , Kaiqiang Zhang 3 , Quyet Van Le 4 , Thang Phan Nguyen 5, 6 , Soo Young Kim 7 , Mohammadreza Shokouhimehr 8
Affiliation  

Venlafaxine (VEN), as one of the popular anti-depressants, is widely utilized for the treatment of major depressive disorder, panic disorder, as well as anxiety. This drug influences the chemicals in the brain, which may result in imbalance in depressed individuals. However, venlafaxine and its metabolites are contaminants in water. They have exerted an adverse influence on living organisms through their migration and transformation in various forms of adsorption, photolysis, hydrolysis, and biodegradation followed by the formation of various active compounds in the environment. Hence, it is crucial to determine VEN with low concentrations in high sensitivity, specificity, and reproducibility. Some analytical techniques have been practically designed to quantify VEN. However, electroanalytical procedures have been of interest due to the superior advantages in comparison to conventional techniques, because such methods feature rapidity, simplicity, sensitivity, and affordability. Therefore, this mini-review aims to present the electrochemical determination of VEN with diverse electrodes, such as carbon paste electrodes, glassy carbon electrodes, mercury-based electrodes, screen-printed electrodes, pencil graphite electrodes, and ion-selective electrodes.

中文翻译:

Venlafaxine电化学传感的最新进展:抗抑郁药和环境污染物。

Venlafaxine(VEN)是一种流行的抗抑郁药,被广泛用于治疗重度抑郁症,惊恐症和焦虑症。该药物影响大脑中的化学物质,可能导致抑郁的个体失衡。但是,文拉法辛及其代谢产物是水中的污染物。它们通过以各种形式的吸附,光解,水解和生物降解的形式迁移和转化,然后在环境中形成各种活性化合物,对生物产生了不利影响。因此,以高灵敏度,特异性和可重复性确定低浓度的VEN至关重要。实际上已经设计了一些分析技术来量化VEN。然而,由于与常规技术相比具有优越的优势,因此电分析方法已引起人们的关注,因为此类方法具有快速,简便,灵敏和价格适中的特点。因此,本微型审查旨在通过各种电极(例如碳糊电极,玻璃碳电极,汞基电极,丝网印刷电极,铅笔状石墨电极和离子选择电极)对VEN进行电化学测定。
更新日期:2020-06-30
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