当前位置: X-MOL 学术Aging Cell › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging.
Aging Cell ( IF 7.8 ) Pub Date : 2020-06-29 , DOI: 10.1111/acel.13161
Marie-Françoise Montaron 1, 2 , Vanessa Charrier 1, 2 , Nicolas Blin 1, 2 , Pierre Garcia 1, 2 , Djoher Nora Abrous 1, 2
Affiliation  

During aging, some individuals are resilient to the decline of cognitive functions whereas others are vulnerable. These inter‐individual differences in memory abilities have been associated with differences in the rate of hippocampal neurogenesis measured in elderlies. Whether the maintenance of the functionality of neurons generated throughout adult life is linked to resilience to cognitive aging remains completely unexplored. Using the immediate early gene Zif268, we analyzed the activation of dentate granule neurons born in adult (3‐month‐old), middle‐aged (12‐month‐old), or senescent (18‐month‐old) rats (n = 96) in response to learning when animals reached 21 months of age. The activation of neurons born during the developmental period was also examined. We show that adult‐born neurons can survive up to 19 months and that neurons generated 4, 10, or 19 months before learning, but not developmentally born neurons, are activated in senescent rats with good learning abilities. In contrast, aged rats with bad learning abilities do not exhibit activity‐dependent regulation of newborn cells, whatever their birthdate. In conclusion, we propose that resilience to cognitive aging is associated with responsiveness of neurons born during adult life. These data add to our current knowledge by showing that the aging of memory abilities stems not only from the number but also from the responsiveness of adult‐born neurons.

中文翻译:

整个成年期产生的齿状神经元的反应性与对认知老化的恢复力有关。

在衰老过程中,一些人对认知功能的衰退有弹性,而另一些人则很脆弱。记忆能力的这些个体间差异与老年人海马神经发生率的差异有关。在整个成年生活中产生的神经元功能的维持是否与对认知老化的恢复力有关,仍然完全没有得到探索。使用即刻早期基因 Zif268,我们分析了成年(3 个月大)、中年(12 个月大)或衰老(18 个月大)大鼠出生的齿状颗粒神经元的激活情况(n = 96) 当动物达到 21 个月大时对学习的反应。还检查了发育期间出生的神经元的激活。我们表明成年出生的神经元可以存活长达 19 个月,并且学习4、10或 19 个月生成的神经元,但不是发育出生的神经元,在具有良好学习能力的衰老大鼠中被激活。相比之下,学习能力差的老年大鼠不会表现出对新生细胞的活动依赖性调节,无论它们的出生日期如何。总之,我们认为对认知衰老的适应力与成年期出生的神经元的反应性有关。这些数据表明,记忆能力的老化不仅源于数量,还源于成人出生神经元的反应能力,从而增加了我们目前的知识。
更新日期:2020-06-29
down
wechat
bug