Obesity is a serious epidemic health problem that can cause many other diseases including type 2 diabetes and cardiovascular diseases. Current approaches to combat obesity suffer from low effectiveness and adverse side effects. Here, a new self‐administrable and minimally invasive transdermal drug delivery strategy for home‐based long‐term treatment of obesity and other diseases is developed. Specifically, ultrathin, core‐shelled, and lance‐shaped polymeric drug reservoirs (micro‐lances [MLs]) are readily fabricated by a thermal pressing molding method and totally implanted into subcutaneous fat by lancing through the skin. Using a diet‐induced obese mouse model, it is shown that the development of obesity and associated metabolic disorders is effectively inhibited by applying therapeutic core‐shelled MLs once every 2 weeks. The outstanding therapeutic effects are attributable to highly localized and biphasic drug release, as well as combination therapy based on browning transformation of white fat and enhanced insulin sensitivity.

中文翻译：

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在皮下脂肪中刺入药物贮库以对抗肥胖症和相关的代谢性疾病。

肥胖是一种严重的流行病，可能导致许多其他疾病，包括2型糖尿病和心血管疾病。当前对抗肥胖症的方法具有功效低和不利的副作用。在这里，开发了一种新的可自我管理且微创的经皮给药策略，用于家庭长期治疗肥胖症和其他疾病。特别是，超薄，核壳和长矛状的聚合物药物储器（微长枪[MLs]）可以通过热压成型方法轻松制造，并通过刺穿皮肤而完全植入皮下脂肪中。使用饮食诱导的肥胖小鼠模型，表明肥胖症和相关代谢紊乱的发生可通过每两周使用一次治疗性带壳ML来有效抑制。