The site‐selective modification of biomolecules has grown spectacularly in recent years. The presence of a large number of functional groups in a biomolecule makes its chemo‐ and regioselective modification a challenging goal. In this context, transition‐metal‐mediated reactions are emerging as a powerful tool owing to their unique reactivity and good functional group compatibility, allowing highly efficient and selective bioconjugation reactions that operate under mild conditions. This Minireview focuses on the current state of organometallic chemistry for bioconjugation, highlighting the potential of transition metals for the development of chemoselective and site‐specific methods for functionalization of peptides, proteins and nucleic acids. The importance of the selection of ligands attached to the transition metal for conferring the desired chemoselectivity will be highlighted.

中文翻译：

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过渡金属介导的生物分子修饰。

近年来，对生物分子的定点选择性修饰得到了惊人的发展。生物分子中大量官能团的存在使其化学和区域选择性修饰成为一个具有挑战性的目标。在这种情况下，过渡金属介导的反应由于其独特的反应性和良好的官能团相容性而成为一种强大的工具，可在温和条件下进行高效且选择性的生物偶联反应。这篇小型综述着重介绍了用于生物缀合的有机金属化学的现状，强调了过渡金属在开发用于肽，蛋白质和核酸功能化的化学选择性和位点特异性方法方面的潜力。