The RZZ complex, composed of the proteins Rough‐Deal (Rod), Zw10 and Zwilch, plays a central role in the spindle assembly checkpoint (SAC), which assures proper sister chromatid segregation during mitosis. RZZ contributes to the regulation of the spindle assembly checkpoint by helping to recruit Mad1–Mad2 and the microtubule motor dynein to unattached kinetochores. It is an important component of the outer kinetochore and specifically the fibrous corona whose expansion is believed to facilitate microtubule capture. How RZZ carries out its diverse activities is only poorly understood. The C‐terminal region of the Rod subunit is relatively well‐conserved across metazoan phylogeny, but no function has been attributed to it.

中文翻译：

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影响 RZZ 动粒功能的 Drosophilarough deal 基因突变

RZZ 复合物由蛋白质 Rough-Deal (Rod)、Zw10 和 Zwilch 组成，在纺锤体组装检查点 (SAC) 中发挥核心作用，可确保在有丝分裂期间正确分离姐妹染色单体。RZZ 通过帮助将 Mad1-Mad2 和微管运动动力蛋白募集到未连接的动粒，有助于调节主轴组装检查点。它是外动粒的重要组成部分，特别是纤维冠的重要组成部分，其扩张被认为有助于微管捕获。RZZ 如何开展其多样化的活动，人们知之甚少。Rod 亚基的 C 端区域在后生动物系统发育中相对保守，但没有归因于它的功能。